The data on histochemical study of changes in the activity of esterases, alpha-glycerophosphate dehydrogenase and the fat content in the chick regenerating liver are presented. The accumulation of the fat in hepatocytes during the early periods of regeneration (1--5th day of the experiment) is partially conditioned by the reduction of the activity of nonspecific esterases. The maximal liver steatosis is accompanied also by an increase in the activity of alpha-glycerophosphate dehydrogenase which indicates intensification of glycolysis and synthesis of triacylglycerines (liver spare lipids) during regeneration.

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