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Objective: To investigate the pharmacodynamics and pharmacokinetics of rocuronium administered by bolus injection to sevoflurane-anesthetized horses.

Study Design: Prospective, experimental, crossover study.

Animals: Five healthy adult Thoroughbred horses (body mass 368-470 kg, three females and two males).

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Background And Purpose: The use of 'bath salts' drug preparations has been associated with high rates of toxicity and death. Preparations often contain mixtures of drugs, including multiple synthetic cathinones or synthetic cathinones and caffeine. Little is known about the interactions of 'bath salts' constituents and adverse effects often reported by users.

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Transcriptome analysis of regenerated dermis stimulated by mechanical stretch.

Gene

January 2025

Department of Plastic Surgery, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi Province 710032, China. Electronic address:

Background: Mechanical stretch is utilized in the process of tissue expansion to promote skin regeneration, which is crucial for wound healing and organ reconstruction purposes. Enlarged dermal area is one of the significant histological characteristics of the expanded skin. However, the underlying biological processes and molecular pathways associated with dermal regeneration triggered by mechanical stretch are still not well understood.

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Purpose: Behavioral and neurobiological abnormalities in addiction and obesity have led to the theory of food addiction in obesity (FAOB) and brain-behavior association studies. Transcranial magnetic stimulation (TMS) studies and treats various brain disorders. Cortico-cortical paired associative stimulation TMS protocol, in which left lateral prefrontal cortex (LPFC) stimulation follows right LPFC stimulation, can reduce emotional reactivity to visual triggers and modulate prefrontal asymmetry in healthy adults.

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Vagus nerve stimulation rescues impaired fear extinction and social interaction in a rat model of autism spectrum disorder.

J Affect Disord

January 2025

Department of Neuroscience, School of Behavioral and Brain Sciences, The University of Texas at Dallas, 800 W Campbell Rd., Richardson, TX 75080, USA; Texas Biomedical Device Center (TxBDC), The University of Texas at Dallas, 800 W Campbell Rd., Richardson, TX 75080, USA. Electronic address:

Clinical diagnosis of anxiety disorders is highly prevalent in autism spectrum disorders (ASD). Available treatments for anxiety offer limited efficacy in the ASD population. Vagus nerve stimulation (VNS) has an anxiolytic effect in rats and, when coupled with fear extinction training, VNS enhances extinction of fear in healthy rats.

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