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Alzheimers Dement
December 2024
Nathan Kline Institute for Psychiatric Research, Orangeburg, NY, USA.
Background: Autophagy-lysosomal pathway (ALP) dysfunction emerges early in Alzheimer's disease(AD). In mouse AD models, lysosomal acidification deficits impair ALP in neurons, in some inducing massive autolysosome accumulations, intraneuronal amyloid plaque, and early neuronal death yielding an extracellular amyloid plaque. This distinctive neurodegenerative pattern (PANTHOS) emerges in early-stage AD and is recapitulated in human late-onset AD (accompanying poster).
View Article and Find Full Text PDF6-Nitrodopamine is an endogenous mediator of rat seminal vesicles contractility.
Andrology
January 2025
Department of Pharmacology, Faculty of Medical Sciences, State University of Campinas (UNICAMP), Campinas, Brazil.
Background: 6-Nitrodopamine (6-ND) released from rat vas deferens acts an endogenous modulator of vas deferens contractility.
Objectives: To investigate whether rat isolated seminal vesicles (RISV) releases 6-ND, the mechanisms involved in the release, and the modulatory role of 6-ND on tissue contractility.
Methods: Rat seminal vesicles were removed and placed in Krebs-Henseleit's solution at 37°C for 30 min, and an aliquot was used to analyze the concentrations of 6-ND, dopamine, noradrenaline, and adrenaline by liquid chromatography with tandem mass spectrometry (LC-MS/MS).
Comprehensive, Quantitative Analysis of SRM 1950: the NIST Human Plasma Reference Material.
Anal Chem
January 2025
Department of Biological Sciences, University of Alberta, Edmonton, Alberta T6G 2E9, Canada.
Article Synopsis
- Multiple analytical techniques were combined to analyze the NIST human plasma reference material SRM 1950, aiming to provide a validated list of metabolite concentration benchmarks for the metabolomics community.
- The study utilized four platforms—high-resolution NMR spectroscopy, direct injection tandem MS, liquid chromatography tandem MS, and inductively coupled plasma MS—resulting in accurate measurements for 728 unique metabolites and an additional 330 identified through literature mining.
- A comprehensive database (SRM1950-DB) with 1,058 metabolites, including information like structures and concentrations, is available online, representing the most thorough quantitative characterization of SRM 1950 to date.
Revealing and mitigating the inhibitory effect of serotonin on HRP-mediated protein labelling.
Sci Rep
December 2024
Neurobiology Division, MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge, CB2 0QH, UK.
Proximity-dependent biotinylation coupled with mass spectrometry enables the characterization of subcellular proteomes. This technique has significantly advanced neuroscience by revealing sub-synaptic protein networks, such as the synaptic cleft and post-synaptic density. Profiling proteins at this detailed level is essential for understanding the molecular mechanisms of neuronal connectivity and transmission.
View Article and Find Full Text PDFMeasuring Alcohol-Induced Striatal Dopamine Release in Healthy Humans With [C]-Raclopride: A Meta-Analysis.
Synapse
January 2025
Department of Science, De La Salle College, Institute of the Brothers of the Christian Schools, Toronto, Ontario, Canada.
Alcohol consumption is known to affect dopamine (DA) release in the brain, with significant implications for understanding addiction and its neurobiological underpinnings. This meta-analysis examined the effects of acute alcohol administration on striatal DA release in healthy humans as measured with [C]-raclopride positron emission tomography (PET). Oral alcohol administration was associated with a significant reduction in [C]-raclopride binding potential (BP) in the ventral striatum (Cohen's d = -0.
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