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Integrated transcriptomics and proteomics analysis of the impact of iodine‑125 in hepatocellular carcinoma.
Mol Med Rep
March 2025
The First Central Clinical School, Tianjin Medical University, Tianjin 300000, P.R. China.
Hepatocellular carcinoma (HCC) is a common cause of cancer‑related mortality and morbidity worldwide. While iodine‑125 (I) particle brachytherapy has been extensively used in the clinical treatment of various types of cancer, the precise mechanism underlying its effectiveness in treating HCC remains unclear. In the present study, MHCC‑97H cells were treated with I, after which, cell viability and proliferation were assessed using Cell Counting Kit‑8, 5‑ethynyl‑2'‑deoxyuridine and colony formation assays, cell invasion and migration were evaluated using wound healing and Transwell assays, and cell apoptosis was determined using flow cytometry.
View Article and Find Full Text PDFUnveiling the Role of Rubber Seals in the Generation of Decentralized Disinfection By-Products in Chlorinated Water Distribution Systems.
Chemosphere
January 2025
University of Chinese Academy of Sciences, Beijing 100049, China; Key Laboratory of Drinking Water Science and Technology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China. Electronic address:
The degradation of rubber seal (RS), particularly ethylene-propylene-diene (EPDM), in the drinking water networks has been confirmed, yet the role of RS as a disinfection by-product (DBP) precursor remains unknown. This study provides explicit proof of the formation of halogenated disinfection by-products (X-DBPs) from RS in chlorinated drinking water within water supply systems. Over time, exposure to chlorinated water ages RS, releasing high levels of organic compounds, which act as DBP precursors.
View Article and Find Full Text PDFAsparagopsis taxiformis supplementation to mitigate enteric methane emissions in dairy cows - effects on performance and metabolism.
J Dairy Sci
January 2025
Department of Applied Animal Science & Welfare, Swedish University of Agricultural Sciences (SLU), Box 7024, 753 23 Uppsala, Sweden.
Methane emissions from ruminant digestion contribute significantly to global anthropogenic greenhouse gas emissions. Members of the phylum Rhodophyta (red algae), particularly Asparagopsis sp., have shown promising results in reducing methane emissions in ruminants, due to their high content of halogenated methane analog compounds.
View Article and Find Full Text PDFFluorescent Heterocyclic Compound-Loaded BiSe-Polysorbate Nanoparticles for Targeted Therapy in Non-Small Cell Lung Cancer.
J Fluoresc
January 2025
Deparment of Hepatobiliary Surgery, The Second Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China.
This study introduces a novel approach for non-small cell lung cancer (NSCLC) treatment by developing BiSe-Polysorbate nanoparticles as a multifunctional platform for photothermal therapy and targeted drug delivery. The BiSe-Polysorbates nanoparticles are engineered as innovative photosensitive drug carriers, enhancing biocompatibility through the combination of BiSe and Polysorbates. Characterization techniques such as Fourier-transform infrared spectroscopy (FT-IR), scanning electron microscopy (SEM), transmission electron microscopy (TEM), and ultraviolet-visible (UV-Vis) spectroscopy confirm the successful synthesis of the nanoparticles.
View Article and Find Full Text PDFCrystal structure and Hirshfeld surface analysis of supra-molecular aggregate of 2,2,6,6-tetra-methyl-piperidin-1-ium bromide with 1,2,3,4-tetra-fluoro-5,6-di-iodo-benzene.
Acta Crystallogr E Crystallogr Commun
January 2025
Department of Chemistry, Bahir Dar University, PO Box 79, Bahir Dar, Ethiopia.
The asymmetric unit of the title compound, CHN·Br·CFI, contains one 2,2,6,6 tetra-methyl-piperidine-1-ium cation, one 1,2,3,4-tetra-fluoro-5,6-di-iodo-benzene mol-ecule, and one uncoordinated bromide anion. In the crystal, the bromide anions link the 2,2,6,6-tetra-methyl-piperidine mol-ecules by inter-molecular C-H⋯Br and N-H⋯Br hydrogen bonds, leading to dimers, with the coplanar 1,2,3,4-tetra-fluoro-5,6-di-iodo-benzene mol-ecules filling the space between them. There is a π-π interaction between the almost parallel benzene rings [dihedral angle = 10.
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