Digitoxin-induced thrombocytopenia.

Int Arch Allergy Appl Immunol

Published: April 1973

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[Digitoxin-induced thrombocytopenia].

Wien Klin Wochenschr

November 1993

4. Medizinische Abteilung, Krankenanstalt Rudolfstiftung, Wien.

A 82-year-old woman was admitted to hospital because of heart failure, vomiting, and pain in the right upper abdomen. During the past three months she had received treatment with 0.07 mg digitoxin twice daily.

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One case of digitoxin-induced thrombopenia with relapse upon reexposure is reported. Cytopenia was each time rapidly reversible upon withdrawal of the medication. During the two episodes, blood digitoxin was superior to the generally accepted value.

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As a result of overdosage a 77-year-old patient with heart disease developed digitoxin intoxication, associated with arrhythmias, extracardiac symptoms of intoxication and severe thrombocytopenia. Treatment with digoxin-specific antibody fragments relieved the signs and symptoms of intoxication within a few hours. The rise in platelet count from the pretreatment value of 26 000/mm3 to 47 000 within 12 h and to over 60 000/mm3 within 16 h of starting the antibody infusion may also be attributed to the treatment with antibodies.

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