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Viscoelasticity of a single poly-protein probed step-by-step during its mechanical unfolding and refolding under the force-clamp conditions.
RSC Adv
January 2025
Faculty of Chemistry, Biological and Chemical Research Centre, University of Warsaw Żwirki i Wigury 101 02-089 Warsaw Poland
One of still outstanding issues in protein folding is to be able to directly observe structural changes occurring along the folding pathway. Herein, we report on changes of the viscoelastic properties for a single protein molecule measured along its mechanically-induced unfolding and refolding trajectories. We use a model system, the I27 poly-protein, and investigate its conformational changes force-clamp AFM (FC-AFM) spectroscopy.
View Article and Find Full Text PDFMultifactorial Analysis of the Collapse Process of Double Bubbles Based on the Coarse-Grained Force Field in Free Domain.
Langmuir
January 2025
Research Center of Fluid Machinery Engineering and Technology, Jiangsu University, Zhenjiang 212013, China.
Cavitation has been a hot research topic for scholars in various fields because of the intense mechanical, chemical, and thermal effects of bubble collapse. It forms a cluster of bubbles, and the bubbles will affect, interfere with, and couple with each other. To grasp the main factors affecting bubble collapse and the interbubble mechanism, the paper adopts the molecular dynamics simulation combined with the coarse-grained force field to study the collapse process of the double bubble model and takes the dynamic shape change of the bubbles, the local velocity distribution, and the local pressure distribution as the object to summarize the position angle, the shock velocity, and the bubble distance on the collapse law and the primary and secondary influence relationship and then reveals the interbubble mechanism.
View Article and Find Full Text PDFSensitivity of coronary hemodynamics to vascular structure variations in health and disease.
Sci Rep
January 2025
Mechanical Engineering, Carnegie Mellon University, Pittsburgh, 15213, USA.
Local hemodynamics play an essential role in the initiation and progression of coronary artery disease. While vascular geometry alters local hemodynamics, the relationship between vascular structure and hemodynamics is poorly understood. Previous computational fluid dynamics (CFD) studies have explored how anatomy influences plaque-promoting hemodynamics.
View Article and Find Full Text PDFContribution of Phosphorylation Modification to Stability and Antibacterial Activity of Egg White Protein Nanogels Loaded with Cinnamon Bark Essential Oil.
Gels
December 2024
College of Food Science and Engineering, Yangzhou University, Yangzhou 225127, China.
This study evaluated the potential usage of phosphorylated egg white protein (P-EWP) nanogels fabricated via microwave-induced phosphorylation modification and gel process and further ultrasonic nanometrization as novel delivery systems for cinnamon bark essential oil (CBEO). Compared to EWP-CBEO nanogels without chemical phosphorylation, the obtained P-EWP-CBEO nanogels have shown smaller average hydrodynamic diameter (133.6 nm), relatively uniform size distribution (polydispersity index around 0.
View Article and Find Full Text PDFAssessing the potential effects of climate change on the morphodynamics of the tropical coral reef islands in the Gulf of Mannar, Indian Ocean.
J Environ Manage
January 2025
Physical Oceanography Division, CSIR- National Institute of Oceanography, Dona Paula, 403 004, Goa, India; School of Oceanography, Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, 201 002, India. Electronic address:
Low-lying and small tropical coral reef islands around the world are extremely vulnerable to the effects of global environmental change caused by the combination of anthropogenic climate change and escalating extreme hydrodynamic events. Erosion and inundation are anticipated to physically destabilize the tropical coral reef islands, rendering them uninhabitable within the next century. Therefore, it is crucial to assess the repercussions of these hazardous events on the delicate reef island ecosystem in order to conserve and ensure sustainable management.
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