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Characterization of cell membrane fragments containing muscle type nAChR from Tetronarce californica after preparation using high pressure homogenization.
Toxicol Lett
January 2025
Bundeswehr Institute for Pharmacology and Toxicology, Neuherbergstraße 11, Munich 80937, Germany. Electronic address:
The nicotinic acetylcholine receptor (nAChR) is a pentameric ligand-gated ion channel (pLGIC) commonly used as a model for receptors belonging to the Cys-loop superfamily. Members of pLGICs are standardly used in numerous toxicological investigations e.g.
View Article and Find Full Text PDFDifferent Time Courses of Mono- and Bi-Liganded Bursts of Channel Openings of Adult nAChR Molecules Formed by the Reactions of Transmembrane Regions.
Cells
December 2024
Institute of Physiology, Department of Neurophysiology, University of Würzburg, Röntgenring 9, 97070 Würzburg, Germany.
We recorded transmembrane currents through single nicotinic acetylcholine receptors (nAChRs) in cell-attached patches at high temporal resolutions from cultured and transiently transfected HEK 293 cells. Receptor activation was elicited by acetylcholine (ACh) or epibatidine (Ebd) at concentrations ranging from 0.01 to 100 µM, binding to one (R or R) or both extracellular ligand binding sites (R).
View Article and Find Full Text PDFPotential molecular mechanisms of tobacco smoke exposure in Alzheimer's disease.
Brain Res
February 2025
Dongguan Key Laboratory of Environmental Medicine, School of Public Health, Guangdong Medical University, Dongguan 523808, People's Republic of China. Electronic address:
Background: Smoking is detrimental to health, with tobacco use being a critical factor in the development of various neurodegenerative diseases, including Alzheimer's disease (AD), which progressively impairs brain function and poses a significant threat to public health. This study aims to examine the potential genetic alterations induced by smoking that are associated with AD and to investigate the underlying regulatory mechanisms. The research will provide theoretical foundations for targeted prevention and treatment strategies for AD.
View Article and Find Full Text PDFEffect of trans 4-butylcyclohexane carboxylic acid (4-BCCA) upon neurodegeneration, oxidative stress related to epileptogenesis in pilocarpine-induced status epilepticus.
Epilepsy Res
January 2025
UCL Queen Square institute of Neurology, Neurology Clinical & Experimental Epilepsy, London, United Kingdom.
Article Synopsis
- - The study investigates the effect of 4-butylcyclohexane carboxylic acid (4-BCCA), a potential epilepsy treatment, in comparison to standard antiseizure medications in a rat model of status epilepticus.
- - 4-BCCA demonstrated effective seizure control and neuroprotection, with the best results observed when combined with the medication perampanel, showing improved memory retention and neuronal viability.
- - The findings suggest that 4-BCCA could be a promising therapeutic option for managing seizures and reducing neurodegeneration in epilepsy, warranting further investigation.
Characterization of Fabry disease-associated lyso-Gb on mouse colonic ion transport and motility.
Am J Physiol Gastrointest Liver Physiol
December 2024
Department of Physiology and APC Microbiome Ireland, University College Cork, Cork, Ireland.
Article Synopsis
- Fabry disease is a rare genetic disorder caused by a deficiency in an enzyme, leading to accumulation of certain lipids in body cells and impacting the gastrointestinal (GI) system, often manifesting early in the disease.
- The study aimed to explore how the lipid lyso-Gb affects ion transport and motility in mouse colons, finding that it increases colonic ion transport without relying on chloride ions or involving the enteric nervous system.
- Results suggest that while lyso-Gb affects ion transport in the colon, other factors may be needed to cause the severe GI issues seen in Fabry disease patients.
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