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Vitamin D modulates the content of inflammatory microRNAs in extracellular vesicles from human adipocyte cells in inflammatory context.
Biofactors
January 2025
Aix Marseille University, INSERM, INRAE, C2VN, Marseille, France.
Inflammation of adipose tissue is a contributing factor to many chronic diseases associated with obesity. We previously showed that micronutrients such as vitamin D (VD) limited this metabolic inflammation by decreasing inflammatory markers expression including miR-155 (microRNA-155) or miR-146a in different in vitro and in vivo models. These miRNAs could be incorporated into extracellular vesicles (EVs) in order to modulate the activity of target cells.
View Article and Find Full Text PDFOpen surgical treatment for giant presacral tailgut cyst - a case report.
S Afr J Surg
December 2024
Department of Gastrointestinal Surgery, Central Hospital Affiliated to Shandong First Medical University, China.
Tailgut cyst is an exceedingly rare congenital anomaly originating from embryonic remnants of the tailgut. Owing to its asymptomatic nature in the early stages, it is prone to clinical misdiagnosis. We present a case of a 55-year-old female with initial symptoms manifesting as sacrococcygeal pain.
View Article and Find Full Text PDFTransabdominal laparoscopic excision of a giant retroperitoneal lymphangioma.
S Afr J Surg
December 2024
Department of Gastrointestinal Surgery, Central Hospital Affiliated to Shandong First Medical University, China.
Retroperitoneal lymphangioma is exceptionally rare. We present a case of a 41-year-old asymptomatic patient with a large abdominal cystic mass detected on contrast-enhanced computed tomography (CT) scan, initially suspected to be pseudomyxoma peritonei. Laparoscopic exploration revealed a 30 x 30 cm multilocular cystic tumour originating from the retroperitoneum.
View Article and Find Full Text PDFColo-colic intussusception secondary to a giant lipoma: A case report.
Radiol Case Rep
March 2025
Department of Radiology, Hôtel-Dieu de France Hospital, Saint Joseph University, Beirut, Lebanon.
Intussusception in adults is a rare condition often associated with a pathological lead point, which is frequently malignant but can occasionally be benign, such as colonic lipomas. We report the case of a 60-year-old male who presented with colicky abdominal pain, and a computed tomography (CT) revealed a colo-colic intussusception caused by a 6 cm lipoma in the transverse colon, accompanied by ischemic changes in the colonic mucosa. The patient underwent a right hemicolectomy, and histopathology confirmed the benign nature of the lesion.
View Article and Find Full Text PDFCase report: A rare case of chondrosarcoma-like malignant giant cell tumor in adolescent rib: diagnostic challenges and treatment.
Front Oncol
January 2025
Department of Thoracic Surgery, Lanzhou University Second Hospital, Lanzhou, Gansu, China.
Chondrosarcoma-like malignant giant cell tumor (GCT) of the rib is an extremely rare and aggressive tumor, particularly in adolescents. This case report describes a 19-year-old female presenting with a GCT of the rib with chondrosarcomatous differentiation, highlighting the challenges posed by its unusual location and pathological complexity. Multidisciplinary diagnostic approaches, including advanced imaging, immunohistochemistry (IHC), and pathology, were essential for confirming the diagnosis.
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