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Developmental exposure of antibiotics shortens life span and induces teratogenicity in .
Toxicol Rep
December 2024
Bioinformatics and Molecular Medicine Research Group, Dow Fly Research Lab and Stock Centre, Dow College of Biotechnology, Dow University of Health Sciences, Karachi 75280, Pakistan.
Antibiotics are the major therapeutic arsenal against bacterial infections. Yet, beneath this medical triumph lies an under investigated challenge of the potential teratological and toxicological impacts associated with the use of antibiotics. In the present study, we have explored the teratogenic potential of five commonly used antibiotics (streptomycin, metronidazole, tigecycline, doxycycline and norfloxacin) on Oregon-R strain.
View Article and Find Full Text PDFTeratological effects of titanium dioxide nanoparticles in mice embryo.
Environ Sci Pollut Res Int
June 2022
Department of Zoology, University of Okara, Okara, 56130, Pakistan.
Nanoparticles have numerous applications related to human uses. Titanium dioxide nanoparticles (TiO-NPs) are extensively used in many daily utilities. The small size particles and larger uses in the industry have led them to become a threatening entity to the living organisms.
View Article and Find Full Text PDFToxicological assessment and developmental abnormalities induced by butylparaben and ethylparaben exposure in zebrafish early-life stages.
Environ Toxicol Pharmacol
November 2020
Faculty of Bioscience and Agro-Food and Environmental Technology, University of Teramo, 64100, Teramo, Italy. Electronic address:
Toxicological effects of butylparaben (BuP) and ethylparaben (EtP) on zebrafish (Danio rerio) early-life stages are not well established. The present study evaluated, using zebrafish embryos and larvae, the toxicity of BuP and EtP through benchmark dose (BMD) approach. BuP was more toxic than EtP to zebrafish larvae.
View Article and Find Full Text PDFThe effects of aliphatic alcohols and related acid metabolites in zebrafish embryos - correlations with rat developmental toxicity and with effects in advanced life stages in fish.
Toxicol Appl Pharmacol
November 2020
Centre for Safety of Substances and Products, National Institute for Public Health and the Environment (RIVM), Bilthoven, the Netherlands.
The zebrafish embryo toxicity test (ZFET) is a simple medium-throughput test to inform about (sub)acute lethal effects in embryos. Enhanced analysis through morphological and teratological scoring, and through gene expression analysis, detects developmental effects and the underlying toxicological pathways. Altogether, the ZFET may inform about hazard of chemical exposure for embryonal development in humans, as well as for lethal effects in juvenile and adult fish.
View Article and Find Full Text PDFAssessment of developmental risk information on medicines for inclusion on the WHO's Essential Medicines List.
Int Health
November 2019
Center for Epidemiology and Environmental Health, CEOH, LLC, Washington, DC, USA.
Background: The WHO develops biannually an Essential Medicines List (EML) of medications proposed for national formularies to be safe, effective and cost-effective. This satisfies the priority healthcare needs of most adult populations, but it does not consider the unique toxicological risks that occur from exposures during pregnancy.
Methods: Developmental toxicity risk information for the 451 specific agents on the 2017 EML were identified from four well-recognized compendia of teratological assessments.
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