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A Novel Open Access Web Portal for Integrating Mechanistic and Toxicogenomic Study Results.
Toxicol Sci
August 2019
Indiana Biosciences Research Institute, 1345 W. 16th St. Suite 300, Indianapolis, IN 46202.
Applying toxicogenomics to improving the safety profile of drug candidates and crop protection molecules is most useful when it identifies relevant biological and mechanistic information that highlights risks and informs risk mitigation strategies. Pathway-based approaches, such as gene set enrichment analysis, integrate toxicogenomic data with known biological process and pathways. Network methods help define unknown biological processes and offer data reduction advantages.
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