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Premedication in upper gastrointestinal endoscopy to improve mucosal visualization. A systematic review.
Rev Gastroenterol Peru
January 2025
Department of Gastroenterology and Endoscopy, Colombia University Clinic, Bogotá, Colombia.
Objective: This review aims to evaluate the efficacy and safety of premedication comprising mucolytics and/or defoaming agents to improve the quality of visualization during elective upper digestive endoscopy (elective upper GI endoscopy) procedure.
Materials And Methods: A systematic review of the literature contained in electronic databases (Medline/Pubmed, Embase, and Lilacs) was performed to identify randomized controlled trials and systematic reviews that assessed patients undergoing upper gastrointestinal endoscopy (elective upper GI Endoscopy) under sedation, after being premedicated with mucolytics and/or defoaming agents for mucous clearance. A meta-analysis was conducted to determine the relative efficacy and safety profile of such premedication.
Helicobacter pylori VacA-induced mitochondrial damage in the gastric pit cells of the antrum and therapeutic rescue.
Biomaterials
March 2025
Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon, 34141, Republic of Korea; KRIBB School of Bioscience, Korea University of Science and Technology, Daejeon, 34113, Republic of Korea; Department of Biological Science, Sungkyunkwan University, Suwon, 16419, Republic of Korea. Electronic address:
Article Synopsis
- The study focuses on VacA, a toxin from Helicobacter pylori, investigating its harmful effects on specific types of stomach cells, particularly how it damages mitochondria and affects cell function.
- Researchers used human gastric organoids (hAGOs) and tissue samples from infected patients to demonstrate that VacA leads to significant mitochondrial damage and reduced energy production, which weakens the stomach's protective barrier.
- The study identified a potential treatment, MLN8054, that can repair VacA-induced mitochondrial damage and restore the integrity of gastric cells, highlighting hAGOs as an effective model for testing new drugs against VacA-related diseases.
Preliminary Identification of Macroconidia (Asexual Forms) of Alternaria Species in Histologic Tissue Sections in a Post Covid Patient with Allergic Fungal Rhinosinusitis.
Turk Patoloji Derg
September 2024
Department of Pathology, Karnataka Institute of Medical Sciences, KARNATAKA, INDIA.
To document a case of `preliminary` identification of Alternaria sp (a phaeohyphomycotic agent) based on morphology in tissue section in a patient with allergic fungal rhinosinusitis. A 25-year-old male, a known asthmatic in a post Covid -19 state, presented with headache, facial swelling and nasal block with discharge of brownish mucoid material. Debrided material from the right maxillary antrum and middle turbinate showed brownish mucoid material admixed with firm to hard degenerated bony spicules sent in formalin and subjected for histopathological examination.
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- Maxillary sinus grafting is a reliable method to increase vertical bone height for easier placement of dental implants in the upper jaw when there's insufficient bone.
- One of the main complications during the procedure is tearing the maxillary sinus membrane, which can lead to graft material entering the sinus, affecting its natural functions.
- The study focuses on how to effectively manage patients with post-surgery CBCT scans showing varying degrees of sinus opacification and presence of bone graft particles, even when they are not experiencing symptoms.
Endoscopic features with linked-color imaging of non- Helicobacter-associated gastritis: a case study.
VideoGIE
March 2024
Department of Gastroenterology, Juntendo University School of Medicine, Tokyo, Japan.
Background And Aims: The endoscopic findings of non- Helicobacter (NHPH) are not widely known. Linked-color imaging (LCI) has emerged as a new system for image-enhanced endoscopy (IEE) that enhances color tone and improves visibility. The aim of this case study was to assess how endoscopic findings of NHPH are enhanced with LCI.
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