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Mechanistic insights regarding neuropsychiatric and neuropathologic impacts of air pollution.

Crit Rev Toxicol

November 2024

Public Health and Integrated Toxicology Division, Center for Public Health and Environmental Assessment, U.S. Environmental Protection Agency, Research Triangle Park, NC, USA.

Air pollution is a significant environmental health risk for urban areas and developing countries. Air pollution may contribute to the incidence of cardiopulmonary and metabolic diseases. Evidence also points to the role of air pollution in worsening or developing neurological and neuropsychiatric conditions.

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Article Synopsis
  • Maternal and child health is increasingly being studied, particularly the impact of prenatal exposure to air pollution (PM) on thyroid function and birth weight.
  • A study involving 446 mother-infant pairs in Ma'anshan, China, found that exposure to PM during late pregnancy was linked to higher maternal thyroid hormone levels and lower birth weight scores.
  • The research indicates that changes in maternal thyroid hormones may mediate the relationship between PM exposure and reduced birth weight, suggesting potential risks for fetal development during this critical period.
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The global incidence of thyroid cancer has increased over the past several decades. While this increase is partially due to increased detection, environmental pollutants have also emerged as a possible contributing factor. Our goal was to perform a systematic review to assess the relationship between environmental air pollution and thyroid cancer.

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Exposure to PM and its constituents in relation to thyroid function of pregnant women: Separate and mixture analyses.

Chemosphere

November 2024

Fujian Maternity and Child Health Hospital, College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fuzhou, China; Fujian Key Laboratory of Women and Children's Critical Disease Research, Fuzhou, China. Electronic address:

The relationships between exposure to PM and its constituents and thyroid hormone (TH) levels in pregnant women are still uncertain, particularly regarding the impact of mixed exposure to PM constituents on thyroid function during pregnancy. This study aimed to investigate the individual and mixed effect of PM and its constituents on TH levels during pregnancy. Fluorescence and chemiluminescence immunoassays were utilized to measure serum concentrations of free thyroxine (FT4) and thyroid-stimulating hormone (TSH) in pregnant women participating in the Fujian Birth Cohort Study (FJBCS).

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Association between air pollutants, thyroid disorders, and thyroid hormone levels: a scoping review of epidemiological evidence.

Front Endocrinol (Lausanne)

October 2024

Department of Endocrinology and Metabolism, Institute of Endocrinology, National Health Commission (NHC) Key Laboratory of Diagnosis and Treatment of Thyroid Disease, The First Hospital of China Medical University, Shenyang, China.

Background: Over the past two decades, the incidence of thyroid disorders has been steadily increasing. There is evidence to suggest that air pollution may be one of the etiological factors of thyroid diseases. This comprehensive review aimed to examine the evidence related to air pollutants and thyroid disorders and thyroid hormones levels from an epidemiological perspective.

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