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Caudally pronounced deficiencies in preplate splitting and migration underly a rostro-caudal progression of cortical lamination defects in the reeler brain.
Cereb Cortex
January 2024
Institute for Neuroanatomy, University Medical Center Göttingen, Göttingen 37075, Germany.
In mammalian neocortex development, every cohort of newborn neurons is guided toward the marginal zone, leading to an "inside-out" organization of the 6 neocortical layers. This migratory pattern is regulated by the extracellular glycoprotein Reelin. The reeler mouse shows a homozygous mutation of the reelin gene.
View Article and Find Full Text PDFCo-cultures of cerebellar slices from mice with different genetic backgrounds as a model to study cortical lamination.
F1000Res
November 2023
Department of Veterinary Sciences, University of Turin, Grugliasco, 10095, Italy.
Reelin has fundamental functions in the developing and mature brain. Its absence gives rise to the Reeler phenotype in mice, the first described cerebellar mutation. In homozygous mutants missing the Reelin gene ( ), neurons are incapable of correctly positioning themselves in layered brain areas such as the cerebral and cerebellar cortices.
View Article and Find Full Text PDFReelin deficiency exacerbates cocaine-induced hyperlocomotion by enhancing neuronal activity in the dorsomedial striatum.
Genes Brain Behav
September 2022
Department of Medicine, University of California, San Diego, La Jolla, California, USA.
The Reln gene encodes for the extracellular glycoprotein Reelin, which regulates several brain functions from development to adulthood, including neuronal migration, dendritic growth and branching and synapse formation and plasticity. Human studies have implicated Reelin signaling in several neurodevelopmental and psychiatric disorders. Mouse studies using the heterozygous Reeler (HR) mice have shown that reduced levels of Reln expression are associated with deficits in learning and memory and increased disinhibition.
View Article and Find Full Text PDFInversion of layer-specific cadherin expression profiles and maintenance of cytoarchitectonic areas in the allocortex of the reeler mutant mouse.
J Comp Neurol
September 2014
Institute of Anatomy, Friedrich Schiller University School of Medicine, Jena University Hospital, 07743, Jena, Germany.
Cadherins are calcium-depending cell adhesion proteins that play critical roles in brain morphogenesis and wiring. They provide an adhesive code for the development of cortical layers, due to their homophilic interactions and their restricted spatiotemporal expression patterns. In the adult organism, cadherins are involved in the maintenance and plasticity of neuronal circuits that play a role in learning.
View Article and Find Full Text PDFLack of reelin modifies the gene expression in the small intestine of mice.
J Physiol Biochem
June 2012
Departamento de Fisiología y Zoología, Universidad de Sevilla, c/o Profesor García González, no. 2, 41012, Sevilla, Spain.
We recently demonstrated that the mucosa of the small intestine of the rat expresses reelin and some components of its signaling system. The current study evaluates whether reelin affects the intestinal gene expression profile using microarray analysis and reeler mice, a natural mutant in which reelin is not expressed. The effect of the mutation on body weight and intestinal morphology is also evaluated.
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