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Cryo-EM structure of the NDH-PSI-LHCI supercomplex from Spinacia oleracea.
Nat Struct Mol Biol
January 2025
Department of Structural Biology, Max Planck Institute of Biophysics, Frankfurt am Main, Germany.
The nicotinamide adenine dinucleotide phosphate (NADPH) dehydrogenase (NDH) complex is crucial for photosynthetic cyclic electron flow and respiration, transferring electrons from ferredoxin to plastoquinone while transporting H across the chloroplast membrane. This process boosts adenosine triphosphate production, regardless of NADPH levels. In flowering plants, NDH forms a supercomplex with photosystem I, enhancing its stability under high light.
View Article and Find Full Text PDFPhotodynamic and photothermal bacteria targeting nanosystems for synergistically combating bacteria and biofilms.
J Nanobiotechnology
January 2025
Shanghai Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine, Shanghai Jiao Tong University, 639 Zhizaoju Road, Shanghai, 200011, China.
The escalating hazards posed by bacterial infections underscore the imperative for pioneering advancements in next-generation antibacterial modalities and treatments. Present therapeutic methodologies are frequently impeded by the constraints of insufficient biofilm infiltration and the absence of precision in pathogen-specific targeting. In this current study, we have used chlorin e6 (Ce6), zeolitic imidazolate framework-8 (ZIF-8), polydopamine (PDA), and UBI peptide to formulate an innovative nanosystem meticulously engineered to confront bacterial infections and effectually dismantle biofilm architectures through the concerted mechanism of photodynamic therapy (PDT)/photothermal therapy (PTT) therapies, including in-depth research, especially for oral bacteria and oral biofilm.
View Article and Find Full Text PDFMetaproteomics reveals metabolic activities potentially involved in bloom formation and succession during a mixed dinoflagellate bloom of Prorocentrum obtusidens and Karenia mikimotoi.
Sci Total Environ
January 2025
State Key Laboratory of Marine Environmental Science/College of the Environment and Ecology, Xiamen University, Xiamen 361005, China; Key Laboratory of Marine Ecology & Environmental Sciences, Institute of Oceanology, Chinese Academy of Sciences, Qingdao 266071, China. Electronic address:
Understanding metabolic activities involved in bloom formation during a single-species algal bloom has improved greatly. However, little is known about metabolic activities during a multi-species algal bloom. Here, we investigated protein expression profiles at different bloom stages of a mixed dinoflagellate bloom caused by Karenia mikimotoi and Prorocentrum obtusidens (syn.
View Article and Find Full Text PDFAnti-TMV activity based flavonol derivatives containing piperazine sulfonyl: Design, synthesis and mechanism study.
Mol Divers
January 2025
State Key Laboratory of Green Pesticide, Center for R&D of Fine Chemicals, Guizhou University, Guiyang, 550025, China.
A series of flavonoid derivatives containing piperazine sulfonate were designed and synthesized. The results of antiviral experiments in vivo showed that some target compounds had good inhibitory effect on tobacco mosaic virus (TMV). The EC values of S15 and S19 curative activity were 174.
View Article and Find Full Text PDFCoumarin derivatives containing the 1,3,4 oxadiazole/thiadiazole moiety discovered as potential anti-tobacco mosaic virus agents.
Mol Divers
January 2025
Environment and Plant Protection Institute, Chinese Academy of Tropical Agricultural Science, Haikou, 571101, China.
In this paper, a series of oxadiazole/thidiazole containing coumarin derivative derivatives were designed, synthesized and characterized using NMR and HRMS. The evaluation of antiviral activity revealed that some of the synthesized compounds exhibited good in vivo antiviral efficacy against tobacco mosaic virus (TMV). Notably, compounds H6 and Y5 demonstrated exceptional therapeutic and protective effects against TMV, with EC values of 180.
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