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The A to Z of Peroral Endoscopic Myotomy.
J Clin Gastroenterol
February 2025
Digestive Disease and Surgery Institute, Cleveland Clinic London, UK.
Peroral endoscopic myotomy (POEM) is a novel technique within the field of third space endoscopy. The overarching principal is creation of a mucosal incision, careful dissection of the submucosal space using an electrosurgical knife to reach the muscularis (ie, tunneling), performing a controlled myotomy, and finally, closure of the mucosal incision. POEM was first developed for the management of achalasia, and now a decade of evidence shows the procedure is safe, effective, and highly reproducible.
View Article and Find Full Text PDFTreatment and Prevention of HPV-Associated Skin Tumors by HPV Vaccination.
Vaccines (Basel)
December 2024
Department of Dermatology, St. Josef Hospital, Ruhr University Bochum, Gudrunstrasse 56, 44791 Bochum, Germany.
HPV-associated dermatological diseases include benign lesions like cutaneous warts and external genital warts. In addition, HPV infection is associated with the development of epithelial skin cancers, in particular cutaneous squamous cell carcinoma (cSCC). In contrast to anogenital and oropharyngeal cancers caused by mucosal HPV types of genus alpha papillomavirus, cSCC-associated HPV types belong to the genus beta papillomavirus.
View Article and Find Full Text PDFNon-invasive screening for laryngeal cancer using the oral cavity as a proxy for differentiation of laryngeal cancer versus leukoplakia: A novel application of ESS technology and artificial intelligence supported statistical modeling.
Am J Otolaryngol
December 2024
Boston University Chobanian and Avedisian School of Medicine, 72 E. Concord Street, Boston, MA 02118, USA; Department of Otolaryngology, Boston Medical Center, 800 Harrison Avenue, Boston, MA 02118, USA. Electronic address:
Objective: This preliminary study tested whether non-invasive, remote Elastic Scattering Spectroscopy (ESS) measurements obtained in the oral cavity can be used as a proxy to accurately differentiate between patients with laryngeal cancer versus laryngeal leukoplakia.
Methods: 20 patients with laryngeal lesions [cancer (n = 10),leukoplakia (n = 10)] were clinically assessed and categorized by otolaryngologists per standard clinical practice. Patient demographics of age, race, sex, and smoking history were collected.
Zoon's Vulvitis and Coexisting Lichen Planus: A Rare Vulval Dermatosis.
Cureus
December 2024
Department of Dermatology, Beaumont Hospital, Dublin, IRL.
This case report describes Zoon's vulvitis or plasma cell vulvitis (PCV) with coexisting lichen planus (LP) treated with methotrexate. PCV is a rare, chronic, benign idiopathic inflammatory condition of the vulvar mucosa, characterized by a bright-red, chronic lesion of mucosa. Typically, it presents as atrophic, shiny, red plaques that can affect any part of the vulva and can spread symmetrically and bilaterally with the propensity of chronicity and gradual coalescence.
View Article and Find Full Text PDFLaryngeal disease classification using voice data: Octave-band vs. mel-frequency filters.
Heliyon
December 2024
Department of Industrial and Data Engineering, Hongik University, Seoul, South Korea.
Introduction: Laryngeal cancer diagnosis relies on specialist examinations, but non-invasive methods using voice data are emerging with artificial intelligence (AI) advancements. Mel Frequency Cepstral Coefficients (MFCCs) are widely used for voice analysis, but Octave Frequency Spectrum Energy (OFSE) may offer better accuracy in detecting subtle voice changes.
Problem Statement: Accurate early diagnosis of laryngeal cancer through voice data is challenging with current methods like MFCC.
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