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Dipeptides in CSF and plasma: diagnostic and therapeutic potential in neurological diseases.
Amino Acids
December 2024
Division of Pediatric Neurology and Metabolic Medicine, Department I, Medical Faculty Heidelberg, Center for Pediatric and Adolescent Medicine, Heidelberg University, Im Neuenheimer Feld 430, 69120, Heidelberg, Germany.
Dipeptides (DPs), composed of two amino acids (AAs), hold significant therapeutic potential but remain underexplored. Given the crucial role of AAs in central nervous system (CNS) function, this study investigated the presence of DPs in cerebrospinal fluid (CSF) and their correlation with corresponding AAs, potentially indicating their role as AA donors. Plasma and CSF samples were collected from 43 children with neurological or metabolic conditions of unknown origin, including 23 with epilepsy.
View Article and Find Full Text PDFHistidine as a versatile excipient in the protein-based biopharmaceutical formulations.
Int J Pharm
September 2024
Institute of Drug Metabolism and Pharmaceutical Analysis, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, Zhejiang 310058, China; Taizhou Institute of Zhejiang University, Taizhou, Zhejiang 317000, China; Innovation Center of Translational Pharmacy, Jinhua Institute of Zhejiang University, Jinhua, 321000, China; Hangzhou Institute of Innovative Medicine, Zhejiang University, Hangzhou, 310016, China. Electronic address:
Article Synopsis
- Adequate stabilization of protein-based biopharmaceuticals is crucial for their durability during manufacturing and storage, and the choice of excipients like histidine plays a key role in this process.
- Histidine, an essential amino acid, is valued for its unique physicochemical properties that allow it to serve multiple functions such as a buffering agent, stabilizer, and antioxidant in formulations.
- This review provides insight into the use of histidine in the biopharmaceutical industry, detailing its benefits, commercial applications, and interactions with proteins, ultimately highlighting both its potential and challenges in formulation strategies.
Computational analysis and expression profiling of two-component system (TCS) gene family members in mango () indicated their roles in stress response.
Funct Plant Biol
June 2024
Integrative Omics and Molecular Modeling Laboratory, Department of Bioinformatics and Biotechnology, Government College University Faisalabad (GCUF), Faisalabad 38000, Pakistan.
The two-component system (TCS) gene family is among the most important signal transduction families in plants and is involved in the regulation of various abiotic stresses, cell growth and division. To understand the role of TCS genes in mango (Mangifera indica ), a comprehensive analysis of TCS gene family was carried out in mango leading to identification of 65 MiTCS genes. Phylogenetic analysis divided MiTCSs into three groups (histidine kinases, histidine-containing phosphotransfer proteins, and response regulators) and 11 subgroups.
View Article and Find Full Text PDFDeveloping Isomeric Peptides for Mimicking the Sequence-Activity Landscapes of Enzyme Evolution.
ACS Appl Mater Interfaces
May 2024
State Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Bioactive Materials of Ministry of Education and College of Life Sciences, Nankai University, Tianjin 300071, China.
Enzymes catalyze almost all material conversion processes within living organisms, yet their natural evolution remains unobserved. Short peptides, derived from proteins and featuring active sites, have emerged as promising building blocks for constructing bioactive supramolecular materials that mimic native proteins through self-assembly. Herein, we employ histidine-containing isomeric tetrapeptides KHFF, HKFF, KFHF, HFKF, FKHF, and FHKF to craft supramolecular self-assemblies, aiming to explore the sequence-activity landscapes of enzyme evolution.
View Article and Find Full Text PDFCarnosine/histidine-containing dipeptide supplementation improves depression and quality of life: systematic review and meta-analysis of randomized controlled trials.
Nutr Rev
February 2025
Department of Medicine, School of Clinical Sciences, Monash University, Melbourne, Australia.
Context: Mental ill-health is a common and growing issue, affecting 1 in 8 individuals or 970 million people worldwide in 2019. Histidine-containing dipeptides (HCDs) have been suggested to mitigate some aspects of mental ill-health, but a quantitative synthesis of the evidence is lacking. Therefore, a systematic review and meta-analysis of randomized controlled trials was conducted.
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