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Outcomes of Coccidioides Seropositive Solid Organ Transplant Recipients After Self-discontinuation of Antifungal Prophylaxis: The EIA-IgM-only Conundrum.
Transplantation
January 2025
Division of Infectious Diseases, Mayo Clinic, Phoenix, AZ.
Background: Solid organ transplant recipients are at risk of severe coccidioidomycosis and are given prophylaxis to mitigate the risk. Patients with seropositive testing typically receive lifelong prophylaxis; currently, this prophylaxis strategy includes patients who are positive only for IgM by enzyme immunoassay (EIA-IgM-only), although this result may be falsely positive.
Methods: We conducted a retrospective study at a large-volume transplant center in an endemic coccidioidomycosis region to compare outcomes of non-lung transplant recipients who were seropositive for Coccidioides but discontinued prophylaxis (case patients) to outcomes of patients who continued prophylaxis (controls).
Emergence of in an asymptomatic Ecuadorian patient with diabetes: A case report.
IDCases
December 2024
Hospital Metropolitano, Av. Mariana de Jesús s/n, Quito 170521, Ecuador.
Coccidioidomycosis is a potentially serious but poorly studied mycosis in Ecuador. It is not a notifiable infection; therefore, its true incidence and prevalence in Ecuador remain unknown. Because primary lung disease due to coccidioidomycoses is typically self-limiting, it does not usually require treatment.
View Article and Find Full Text PDFLightning Can Strike Twice: Management of an Infant With Anomalous Left Coronary Artery from the Pulmonary Artery Complicated by Coccidioidomycosis Infection.
World J Pediatr Congenit Heart Surg
January 2025
Department of Pediatrics (Cardiology), University of Arizona, Tucson, AZ, USA.
Cardiac disease in young children can be unrecognized until symptoms are unmasked by a precipitating event, such as an infection. We present a case of anomalous left coronary artery from the pulmonary artery causing clinically significant disease in a four-month-old male with concomitant mitral regurgitation and pulmonary coccidioidomycosis who required modification of his surgical management due to the infection. This case highlights how timely diagnosis and perioperative management and recovery can be affected by concurrent infections in patients with congenital heart disease.
View Article and Find Full Text PDFPulmonary coccidioidomycosis presenting as a fungal ball mimicking aspergilloma.
Med Mycol Case Rep
March 2025
Department of Medical Microbiology, Radboud University Medical Centre, Nijmegen, the Netherlands.
A 49-year old female, known to have had an asymptomatic pulmonary cavity since 2015, presented in 2023 with hemoptysis. Radiology showed a mass suspected to be an aspergilloma. Due to persistent hemoptysis, lobectomy was performed.
View Article and Find Full Text PDFEfficient Method for Imaging Murine Lungs that Preserves Spatial Dynamics of Fungal Spores in the Airways.
J Vis Exp
December 2024
Department of Medicine, New Jersey Medical School, Rutgers - The State University of New Jersey;
Fungi infect humans when environmental spores are inhaled into the lungs. The lung is a heterogeneous organ. Conducting airways, including bronchi and bronchioles, branch until terminating in the alveolar airspace where gas exchange occurs.
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