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HYDROGEN SULFIDE AND CYSTATHIONINE γ-LYASE LEVELS FOR PATIENTS WITH PARKINSON'S DISEASE.
Georgian Med News
November 2024
2Department of Chemistry, College of Science, University of Mosul, Iraq.
Parkinson's disease (PD) is a complicated neurodegenerative disease that is the most prevalent severe movement disorder worldwide. The research includes studying the levels of hydrogen sulphide (H2S) and cystathionine γ-lyase (CSE) with some biochemical parameters in the serum of patients with PD in Mosul City (Iraq), which include Serotonin (SERT), dopamine (DA), sphingomyelin (SM), vitamin B12, Acetylcholine esterase (AChE), monoamine oxidase (MAO), creatine kinase (CK), aspartate aminotransferase (AST), alanine aminotransferase (ALT). Samples reached (100), which included: (40) for the Parkinson's patients group, and (60) for the control group.
View Article and Find Full Text PDFAdverse effects of diethyl phthalate and butyl benzyl phthalate on circadian rhythms and sleep patterns in zebrafish larvae.
Ecotoxicol Environ Saf
December 2024
Center for Predictive Model Research, Division of Advanced Predictive Research, Korea Institute of Toxicology, Daejeon, 34114, Korea; Human and Environmental Toxicology, University of Science and Technology, Daejeon 34113, South Korea. Electronic address:
The zebrafish, a diurnal vertebrate, is commonly used in circadian rhythm studies due to its genetic and neurological similarities to humans. Circadian rhythms, which regulate sleep, neurotransmitter, behavior, and physiological responses to environmental changes, can be disrupted by various environmental factors. Phthalic acid esters (PAEs) are pervasive endocrine disruptors that individuals are frequently exposed to in daily life.
View Article and Find Full Text PDFMexican calea (Calea zacatechichi Schltdl.) interferes with cholinergic and dopaminergic pathways and causes neuroglial toxicity.
J Ethnopharmacol
January 2025
REQUIMTE/LAQV, Laboratório de Farmacognosia, Departamento de Química, Faculdade de Farmácia, Universidade do Porto, R. Jorge Viterbo Ferreira, nº 228, 4050-313, Porto, Portugal. Electronic address:
Ethnopharmacological Relevance: The use of "Mexican calea" (Calea zacatechichi Schltdl.) in ritualistic ceremonies, due to its dream-inducing effects, was until recently limited to indigenous communities in Mexico. However, the plant has recently gained popularity in Western societies being commonly used in recreational settings.
View Article and Find Full Text PDFNeurotoxicity and intestinal microbiota dysbiosis induced by per- and polyfluoroalkyl substances in crucian carp (Carassius auratus).
J Hazard Mater
October 2024
Department of Microbiology and Synthetic Biology, School of Life Science and Technology, China Pharmaceutical University, Nanjing 210009, China. Electronic address:
Article Synopsis
- PFAS, known as "forever chemicals," exhibit chemical stability and have potential harmful effects on aquatic life, specifically investigated in crucian carp at environmentally relevant concentrations (200 ng/L).
- The study found that PFAS exposure negatively impacted the behavior of crucian carp, decreased neurotransmitter levels in the brain, and altered vital enzyme activities, indicating potential neurotoxic and oxidative stress effects.
- Additionally, PFAS exposure led to significant changes in the gut microbiota of the fish, promoting the growth of harmful bacteria and causing tissue damage, highlighting the need for further assessment of PFAS toxicity in aquatic environments.
Acetylcholinesterase and dopamine inhibition suppress the filtration rate, burrowing behaviours, and immunological responses induced by bisphenol A in the hemocytes and gills of date mussels, Lithophaga lithophaga.
Aquat Toxicol
July 2024
Biotechnology Department, Institute of Graduate Studies and Research, Alexandria University, Alexandria, Egypt.
Bisphenol A (BPA), a common industrial chemical with estrogenic activity, has recently gained attention due to its well-documented negative effects on humans and other organisms in the environment. The potential immunotoxicity and neurotoxicity of BPA remain poorly understood in marine invertebrate species. Therefore, the impacts of exposure to BPA on a series of behaviours, immune responses, oxidative stress, neural biomarkers, histology, and the ultrastructure of gills were investigated in the date mussel, Lithophaga lithophaga.
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