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Protective effect of low-dose lactulose in dextran sulfate sodium induced ulcerative colitis model of rats.
Sci Rep
January 2025
Department of Gastroenterology, The First Affiliated Hospital of Xinjiang Medical University, No.137 LiYuShan Road Xinjiang Province, Urumqi, 830000, China.
Although low-dose lactulose has shown a good theoretical foundation for the treatment of ulcerative colitis (UC) in previous studies, the exact effects and mechanism remain unclear. The rats were randomly distributed into 5 groups, i.e.
View Article and Find Full Text PDFDelayed Stevens-Johnson syndrome induced by combined administration of carbamazepine and botulinum toxin: A case report.
Medicine (Baltimore)
January 2025
Department of Rehabilitation Medicine, Hebei General Hospital, Shijiazhuang, Hebei, China.
Rationale: Steven-Johnson syndrome (SJS) is characterized by severe illness, rapid progression, and high mortality rates, with the vast majority of cases induced by medications. Botulinum toxin, a neurotoxin produced by Clostridium botulinum, has not been reported in the literature as a causative agent of SJS.
Patient Concerns: A 56-year-old male patient, who underwent surgery for cerebral hemorrhage, developed widespread patchy annular papules following the injection of botulinum toxin into the masseter muscle.
Lactulose use among patients with alcohol-related liver cirrhosis as a surrogate marker of hepatic encephalopathy: prevalence and association with mortality - a Danish nationwide cohort study.
Metab Brain Dis
January 2025
Department of Hepatology and Gastroenterology, Aarhus University Hospital, Aarhus N, Denmark.
Background & Aims: Hepatic encephalopathy (HE), one of the most serious prognostic factors for mortality in alcohol-related cirrhosis (ALD cirrhosis), is not recorded in Danish healthcare registries. However, treatment of HE with lactulose, the universal first-line treatment, can be identified through data on filled prescriptions. This study aimed to investigate if lactulose can be used as a surrogate marker of HE.
View Article and Find Full Text PDFAnalysis of the efficacy of lactulose combined with polyethylene glycol in the treatment of functional constipation.
Am J Transl Res
December 2024
Anorectal Department, Suining Central Hospital Suining 629000, Sichuan, China.
Objectives: This study focuses on analyzing the efficacy of lactulose oral solution combined with Macrogol 4000 Powder in the treatment of functional constipation (FC).
Methods: A total of 125 FC patients were selected, with 60 cases in a control group, who were treated with lactulose oral solution alone, and 65 cases in a research group, who were treated with lactulose oral solution combined with Macrogol 4000 Powder. The two groups were analyzed and compared in terms of efficacy, symptom recovery, Bristol Stool Form Scale (BSFS) and Wexner Constipation Scale (WCS) scores, adverse effects, serum indices, and Patient Assessment of Constipation Quality of Life (PAC-QOL).
A smart probe for detection of sugar markers for applications in gastrointestinal barrier dysfunction.
Biosens Bioelectron
March 2025
Bio-Acoustic MEMS in Medicine (BAMM) Laboratory, Canary Center at Stanford, Department of Radiology, Stanford School of Medicine, Stanford University, Palo Alto, CA, 94304, USA. Electronic address:
Article Synopsis
- Gastrointestinal (GI) barrier dysfunction is a critical early indicator of multiple complex diseases, but current testing methods for saccharide molecules used to assess this function are expensive and time-consuming.
- A new one-component system utilizing a naphthyl-pyridine core and boronic acid receptor has been developed for the early detection of saccharide biomarkers like lactulose, which indicates GI barrier issues.
- The innovative design incorporates a scalable 96-well format with gold nanoparticles and combines plasmonics and fluorescence for sensitive lactulose quantification, aiming to create an affordable and portable diagnostic tool for routine GI permeability testing.
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