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The variability in pattern, presentation, and outcomes in the management of congenital corrected transposition of the great artery (ccTGA): A Systematic Review and Meta-analysis.
Niger Med J
January 2025
Division of Paediatric Cardiology, Limi Children's Hospital, Abuja, Nigeria.
Background: Congenitally corrected transposition of the great arteries (ccTGA) is a rare congenital heart disease with varying regional reports in management approach. The meta-analysis is aimed to document various regional differences in the pattern, presentation, and outcomes in the management of congenitally corrected transposition of the great artery(ccTGA).
Methodology: Search engines for published articles on ccTGA were used in the meta-analysis.
Mixed reality for preoperative planning and intraoperative assistance of surgical correction of complex congenital heart defects.
J Thorac Cardiovasc Surg
January 2025
Division of Cardiology, The Hospital for Sick Children, Toronto, ON, Canada; Center for Image Guided Innovation and Therapeutic Intervention, The Hospital for Sick Children, Toronto, ON, Canada.
Objectives: Mixed reality (MixR) is an innovative visualization tool that presents virtual elements in a real-world environment, enabling real-time interaction between the user and the combined digital/physical reality. We aimed to explore the feasibility of MixR in enhancing preoperative planning and intraoperative guidance for the correction of various complex congenital heart defects (CHDs).
Methods: Patients underwent cardiac computed tomography or cardiac magnetic resonance and segmentation of digital imaging and communications in medicine (DICOM) images was performed.
Ventricular lead malfunction in a patient with complete atrioventricular block and corrected transposition of the great arteries: Is leadless pacemaker the best solution?
J Cardiol Cases
October 2024
Second Division of Cardiology, Pisa University Hospital, Pisa, Italy.
Unlabelled: Corrected transposition of the great arteries (c-TGA) is a congenital abnormality characterized by atrioventricular (AV) and ventriculoarterial discordance, associated with early and late-onset conduction disturbances. We report the case of a c-TGA patient affected by congenital complete AV block, with right ventricular lead malfunction with prolonged dwell time and two abandoned leads. He underwent leadless VDD pacemaker implantation at an unusual site (i.
View Article and Find Full Text PDFArrhythmia Burden in Congenitally Corrected Transposition of the Great Arteries (cc-TGA): Does Treatment Pathway Matter?
Heart Rhythm
January 2025
Children's Institute Department of Heart, Vascular & Thoracic, Division of Cardiology & Cardiovascular Medicine, Cleveland Clinic Children's, Cleveland, Ohio. Electronic address:
Background: There is limited data comparing arrhythmia burden amongst patients with congenitally corrected transposition of the great arteries (cc-TGA) undergoing anatomic repair (AR), physiologic repair (PR), and non-surgical management (NS).
Objective: To examine the difference in rate of brady- and tachyarrhythmias amongst patients with cc-TGA stratified by treatment pathway.
Methods: A retrospective cohort study was conducted including all patients with cc-TGA followed at Cleveland Clinic Children's (1995-2021).
Integrating single-cell multimodal epigenomic data using 1D convolutional neural networks.
Bioinformatics
December 2024
Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI 48109, United States.
Motivation: Recent experimental developments enable single-cell multimodal epigenomic profiling, which measures multiple histone modifications and chromatin accessibility within the same cell. Such parallel measurements provide exciting new opportunities to investigate how epigenomic modalities vary together across cell types and states. A pivotal step in using these types of data is integrating the epigenomic modalities to learn a unified representation of each cell, but existing approaches are not designed to model the unique nature of this data type.
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