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Screening analysis of doping agents in horse urine and plasma with dilute and shoot using liquid chromatography high resolution mass spectrometry.
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January 2025
Department of Comparative Biomedical Sciences, School of Veterinary Medicine, Louisiana State University, Baton Rouge, LA, 70803, USA.
Various technical methodologies are required to accurately detect substances of different chemical and pharmacological properties in biological samples, which are increasing in number and variety daily. Therefore, laboratories where many samples and different factors are analyzed simultaneously need methods with easy sample preparation, short analysis times and low analysis costs. In this study, the objective was to scan substances susceptible to chemical degradation, amenable to analysis without hydrolysis, and exhibiting short-term stability by employing a straightforward, expeditious, and cost-efficient method.
View Article and Find Full Text PDFCoupling high-throughput and modeling approaches to streamline early-stage process development for biologics.
Biotechnol Prog
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Purification Development, Genentech, South San Francisco, California, USA.
Platforms have long been implemented for downstream process development of monoclonal antibodies (mAbs) to streamline development and reduce timelines. These platforms are also increasingly being used for other complex biologics modalities. While development has traditionally been conducted at the lab bench scale in a sequential manner, automated miniaturized and parallelized approaches like RoboColumns and resin plates have also been implemented for chromatographic screening.
View Article and Find Full Text PDFBroad-spectrum affinity chromatography of SARS-CoV-2 and Omicron vaccines from ligand screening to purification.
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Department of Biochemical Engineering, School of Chemical Engineering and Technology, Tianjin University, Tianjin 300350, China; Key Laboratory of Systems Bioengineering and Frontiers Science Center for Synthetic Biology (Ministry of Education), Tianjin University, Tianjin 300350, China. Electronic address:
Emerging variants of SARS-CoV-2 pose great technological and regulatory challenges to vaccine manufacturing, especially in downstream processing. To address this dilemma, the development of broad-spectrum affinity chromatography for the purification of wild-type SARS-CoV-2 and its variants is crucial. We propose a comprehensive strategy to achieve this goal via the identification of high-affinity peptides by affinity selection of phage display and next-generation sequencing (NGS) and the evaluation of chromatographic performance.
View Article and Find Full Text PDFAnalytical and Applied Copyrolysis of L. and Polyethyelene Terephthalate Plastic for Hydrocarbon-Rich Bio-oil.
ACS Omega
January 2025
Department of Chemical Engineering, Indian Institute of Technology Guwahati, Guwahati 781039, India.
The current investigation focuses on the copyrolysis of L. (a nonedible oilseed, also known as Nahar) and polyethyelene terephthalate (PET) plastic waste to gain insights into the composition of pyrolysates and the thermal decomposition of complex and mixed feedstocks. The physicochemical properties of the feedstocks were studied through thermogravimetric analysis at a heating rate of 15 °C min, bomb calorimetry, and proximate/ultimate analysis.
View Article and Find Full Text PDFMethod Validation for Estimation of Imidacloprid and its Metabolites in Maize and Soil by LCMS-MS.
J Chromatogr Sci
January 2025
Pesticide Residue Analysis Laboratory, Department of Entomology, Punjab Agricultural University, Ludhiana 141004, Punjab, India.
Validation of Quick, Easy, Cheap, Effective, Rugged, and Safe (QuEChERS) method was performed for estimation of imidacloprid (IM) and its metabolites in maize leaves, immature kernels, mature kernels, stalk, and soil using liquid chromatograph tandem mass spectrometry, coupled with electrospray ionization. The extraction in different matrices of maize and soil was performed using acetonitrile +0.1% formic acid followed by clean-up with primary secondary amine sorbent and anhydrous magnesium sulfate.
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