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| http://dx.doi.org/10.1136/ard.31.6.474 | DOI Listing |
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Recent Advances in Managing Ankylosing Spondylitis with Andersson Lesion: A Clinical Overview and Case Report.
J Orthop Case Rep
January 2025
Department of Orthopaedics, Saveetha Institute of Medical and Technical Sciences, Chennai, Tamil Nadu, India.
Introduction: Ankylosing spondylitis (AS) is a chronic inflammatory disorder that primarily affects the spine and sacroiliac joints, leading to pain, stiffness, and progressive thoracolumbar kyphotic deformity. A key complication in advanced AS is the development of Andersson lesions (AL), degenerative vertebral lesions resulting from the disease's progression. These lesions can cause significant mechanical pain, often mistaken for the chronic discomfort associated with AS.
View Article and Find Full Text PDFFive Cases of Non-radiographic Spondyloarthritis (nr-SpA) of Patients from a Tertiary Care Center in the Philippines: A Case Series.
Acta Med Philipp
November 2024
Department of Medicine, Makati Medical Center.
Axial Spondyloarthritis (SpA) is a chronic inflammatory disease of the spine associated with the gene HLA-B27. Non-radiographic spondyloarthritis (nr-SpA), an early stage of axial SpA often goes unrecognized in many settings including the Philippines. We describe five Filipinos from a tertiary health care facility who fulfill the Assessment of SpondyloArthritis International Society (ASAS) 2009 criteria for non-radiographic SpA with the aim of increasing awareness of this disease in the Philippines.
View Article and Find Full Text PDFAnatomy-centred deep learning improves generalisability and progression prediction in radiographic sacroiliitis detection.
RMD Open
December 2024
Department of Gastroenterology, Infectious Diseases and Rheumatology (incl. Nutrition Medicine), Charite - Universitatsmedizin Berlin, Berlin, Germany.
Purpose: To examine whether incorporating anatomy-centred deep learning can improve generalisability and enable prediction of disease progression.
Methods: This retrospective multicentre study included conventional pelvic radiographs of four different patient cohorts focusing on axial spondyloarthritis collected at university and community hospitals. The first cohort, which consisted of 1483 radiographs, was split into training (n=1261) and validation (n=222) sets.
Disease Activity and Bone Microarchitectural Phenotype in Patients With Axial Spondyloarthritis.
HSS J
July 2024
Division of Endocrinology, Department of Medicine, Hospital for Special Surgery, New York City, NY, USA.
Background: Axial spondyloarthritis (AxSpA) is a chronic rheumatic disease characterized by spine inflammation, abnormal bone growth, and paradoxically osteoporosis and vertebral fractures. The pathogenesis of skeletal deficits in this disease is poorly understood.
Purpose: We sought to evaluate volumetric bone mineral density (vBMD) and bone microarchitecture in patients with AxSpA and to identify disease-related factors associated with skeletal abnormalities.
The lipid paradox is also present in early axial spondyloarthritis: results from the Swedish part of the SPondyloArthritis Caught Early (SPACE) cohort.
Scand J Rheumatol
October 2024
Rheumatology, Department of Clinical Sciences, Lund University, Malmö, Sweden.
Article Synopsis
- This study investigates the relationship between systemic inflammation and cholesterol levels in early axial spondyloarthritis (axSpA), an area that has not been extensively researched before.* -
- The research examined 64 patients, finding that higher levels of C-reactive protein (CRP) were associated with lower total cholesterol (TC) and two types of apolipoproteins (ApoA1 and ApoB), especially after adjusting for age, sex, and other factors.* -
- The results suggest that the "lipid paradox" seen in other inflammatory conditions also applies to early axSpA, highlighting the need to consider lipid levels when assessing cardiovascular disease risk in these patients.*
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