Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Chagas disease treatment efficacy markers: experiences from a Phase III study with nifurtimox in children.
Front Parasitol
September 2023
Research and Development Pharmaceuticals, Bayer AG, Wuppertal, Germany.
Determining the success of antitrypanosomal therapy for Chagas disease is challenging, particularly in the chronic phase of the disease, because seropositivity persists for a long time after successful antitrypanosomal treatment and is known to be related to the duration of infection. Seroconversion to negative by two or more conventional serologic tests is the currently accepted measure of efficacy, and studies suggest no significant change in seropositivity if left untreated. However, there is no guidance for industry on how to establish the effectiveness of drugs intended for the treatment of Chagas disease.
View Article and Find Full Text PDFChagas Disease in the New York City Metropolitan Area.
Open Forum Infect Dis
May 2020
Division of Infectious Diseases, Albert Einstein College of Medicine and Jacobi Medical Center, Bronx, New York, USA.
Background: Chagas disease, caused by the parasite , once considered a disease confined to Mexico, Central America, and South America, is now an emerging global public health problem. An estimated 300 000 immigrants in the United States are chronically infected with However, awareness of Chagas disease among the medical community in the United States is poor.
Methods: We review our experience managing 60 patients with Chagas disease in hospitals throughout the New York City metropolitan area and describe screening, clinical manifestations, EKG findings, imaging, and treatment.
Usefulness of real-time PCR during follow-up of patients treated with Benznidazole for chronic Chagas disease: Experience in two referral centers in Barcelona.
PLoS Negl Trop Dis
February 2020
Department of Microbiology, Vall d'Hebron University Hospital, Universitat Autònoma de Barcelona PROSICS, Barcelona, Spain.
Background: Antitrypanosomal treatment with Benznidazole (BZ) or Nifurtimox may be recommended for patients with chronic Chagas disease (CD) to reduce the onset or progression of symptoms. However, such treatment has limited efficacy and high level of toxic effects. In addition, the current cure biomarker (serology conversion) precludes any treatment assessment unless a prolonged follow-up is arranged.
View Article and Find Full Text PDFCardiac surgery for Chagas disease.
J Card Surg
October 2018
Jackson Memorial Hospital-University of Miami Miller School of Medicine, Department of Surgery, Division of Cardiothoracic Surgery, Miami, Florida.
Although Chagas disease is a rare entity in North America, it is associated with significant cardiac morbidity. It is estimated that 20-30% of those who are infected will eventually develop cardiovascular disease secondary to Chagas disease. We review the literature and share our experience on the surgical management of this challenging patient population.
View Article and Find Full Text PDFMortality trends and risk factors in advanced stage-2 Human African Trypanosomiasis: A critical appraisal of 23 years of experience in the Democratic Republic of Congo.
PLoS Negl Trop Dis
June 2018
Départment de Neurologie, Université de Kinshasa, Kinshasa, République Démocratique du Congo (RDC).
We conducted a retrospective study on mortality trends and risk factors in 781 naïve cases of advanced stage-2 sleeping sickness admitted between 1989 and 2012 at the National Reference Center for Human African Trypanosomiasis (HAT), Department of Neurology, Kinshasa University, Democratic Republic of Congo (DRC). Death was the outcome variable whereas age, gender, duration of disease, location of trypanosomes in body fluids, cytorachy, protidorachy, clinical status (assessed on a syndromic and functional basis) on admission, and treatment regimen were predictors in logistic regression models run at the 0.05 significance level.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!