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Objectives: This study was designed to compare the clinical data of vesicoureteral reflux (VUR) in children with and without an allergic constitution.

Methods: The clinical data of patients hospitalized with VUR due to a urinary tract infection (UTI) between September 1, 2019, and December 31, 2020, were retrospectively analyzed. The patients were divided into two groups: an anallergic constitution group (AC group) and a non-allergic constitution (NAC group), and their UTIs and VUR were compared at baseline and during the follow-up period.

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Robot-assisted Laparoscopic Ureteral Reimplantation in Pre-toilet Trained Children With Vesicoureteral Reflux.

Urology

January 2025

Division of Urology, Children's Hospital of Philadelphia, Philadelphia, PA; Division of Urology, Hospital of the University of Pennsylvania, Perelman Center for Advanced Care, Philadelphia, PA. Electronic address:

Article Synopsis
  • The study evaluated the outcomes of robot-assisted laparoscopic ureteral reimplantation (RALUR) for treating primary vesicoureteral reflux (VUR) in pre-toilet trained children, comparing results to a group of toilet trained children.
  • Researchers analyzed data from 158 patients, noting similar demographics and surgical outcomes between the two groups despite the pre-toilet trained group having more severe VUR grades.
  • The findings indicate that RALUR is a safe and successful treatment option for both groups, making it a valid alternative to traditional open surgery.
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Article Synopsis
  • The study investigated the role of sonic hedgehog (SHH) protein in the development of bladder and ureter smooth muscle in children with vesicoureteral reflux (VUR) after ureteroneocystostomy operations.
  • Researchers analyzed 28 ureterovesical junction segments from 19 children using Western Blot to measure SHH protein expression levels against β-Actin as a control.
  • Results indicated that while SHH was present, there was no significant correlation between SHH levels and the severity of VUR, suggesting that SHH may play a role in the condition's development rather than its severity.
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Primary vesicoureteral reflux.

Nat Rev Dis Primers

October 2024

Departments of Paediatrics (Nephrology) and Urology, Wayne State University School of Medicine, Detroit, MI, USA.

Article Synopsis
  • Primary vesicoureteral reflux (VUR) is a common condition in children where urine flows backward from the bladder, leading to urinary tract infections and potential kidney damage.
  • The primary goals for treating VUR in kids are to prevent UTIs and reduce the risk of kidney problems, with available management options including antibiotics, surveillance, and various surgical techniques.
  • Ongoing debates focus on the timing of imaging tests and identifying which patients will benefit most from either antibiotics or surgical treatments, with new technologies like artificial intelligence offering future support in decision-making.
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Article Synopsis
  • The demand for kidney transplants has led to the use of organs from expanded criteria donors, which increases the risk of complications like primary non-function and delayed graft function.
  • Current diagnostic tools for assessing kidney quality before transplantation are lacking, and existing predictive models have proven insufficient.
  • New methods like liquid chromatography-mass spectrometry (LC-MS) and microarrays are being explored to analyze proteins in preservation solutions, potentially improving the ability to assess kidney quality prior to transplant.
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