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Airway constriction measured from tantalum bronchograms in conscious mice in response to methacholine.
J Appl Physiol (1985)
September 2008
Center for Biomedical Engineering, Univ. of Kentucky, Lexington, KY 40506-0070, USA.
A single-projection X-ray technique showed an increase in functional residual capacity (FRC) in conscious mice in response to aerosolized methacholine (MCh) with little change in airway resistance (Raw) measured using barometric plethysmography (Lai-Fook SJ, Houtz PK, Lai Y-L. J Appl Physiol 104: 521-533, 2008). The increase in FRC presumably prevented airway constriction by offsetting airway contractility.
View Article and Find Full Text PDFAirway strain during mechanical ventilation in an intact animal model.
Am J Respir Crit Care Med
October 2007
Department of Physiology, University of Tennessee Health Science Center, 894 Union Avenue, Nash 426, Memphis, TN 38163, USA.
Rationale: Mechanical ventilation with large tidal volumes causes ventilator-induced lung injury in animal models. Little direct evidence exists regarding the deformation of airways in vivo during mechanical ventilation, or in the presence of positive end-expiratory pressure (PEEP).
Objectives: To measure airway strain and to estimate airway wall tension during mechanical ventilation in an intact animal model.
[Evaluation of the functional activity of the bronchial mucosa in pulmonary tuberculosis and other lung diseases].
Probl Tuberk Bolezn Legk
April 2004
Tracheobronchography using tantal powder was used to study the functional activity of the intact and altered bronchial mucosa that manifested itself as the unchanged outline of the mucosa and its clearance (mucociliary clearance). With the intact mucosa, the sequence of its clearance was established; the mechanism of powder transport was studied, which showed up as the appearance of metachronal fields, fusion of particles into conglomerates that form currents that direct towards the larynx. The clearance of the mucosa was over by hours 20-24.
View Article and Find Full Text PDFDirect in vivo visualization of bronchodilation induced by inhalational anesthesia using high-resolution computed tomography.
Anesthesiology
February 1993
Department of Anesthesiology and Critical Care Medicine, Johns Hopkins Medical Institutions, Baltimore, Maryland.
Background: Volatile anesthetics are effective at preventing and reversing bronchospasm, but their effects on baseline airway tone are controversial. While tantalum bronchography has been used in the past to measure one-dimensional airway diameter changes, this method has inherent problems associated with the irritant effects of tantalum. Until recently, no other direct noninvasive in vivo method to assess airway caliber was available.
View Article and Find Full Text PDFEffect of maturation on topographic distribution of bronchoconstrictor responses in large diameter airways of young swine.
Am Rev Respir Dis
January 1991
Department of Pediatrics, University of Chicago, Illinois 60637.
We studied the effect of maturation on the topographic distribution of airway constriction in Generations 0 (trachea) through 6 in fourteen 2-wk-old swine (2ws) and sixteen 10-wk-old swine (10ws) in vivo and in excised airways from seven 2ws and seven 10ws in vitro. Animals were anesthetized with chloralose-urethane and received beta-adrenergic blockade and vagotomy prior to generation of random-order, dose-response curves with i.v.
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