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Tetrafocal Bone Lengthening by Ilizarov Frame Application in a Patient With Segmental Tibial Bone Loss: A Case Report.
JBJS Case Connect
January 2025
Department of Surgery, The Aga Khan University, Karachi, Pakistan.
Case: Thirty-five-year-old man presented with 14 cm segmental tibial defect after crush injury (Gustilo Anderson type-IIIA). Tetrafocal bone transport using Ilizarov frame was performed with 3 osteotomies. Two minor complications-skin invagination and failure at proximal docking site-were addressed.
View Article and Find Full Text PDFScratching more than an itch.
Science
January 2025
Divison of Allergy and Immunology, John T. Milliken Department of Medicine, Washington University School of Medicine in St. Louis, St. Louis, MO, USA.
Enhanced antibacterial skin inflammation is an adaptation of the itch-scratch cycle.
View Article and Find Full Text PDFPrognostic value of immune biomarkers in melanoma loco-regional metastases.
PLoS One
January 2025
Department of Clinical Medicine, Centre for Cancer Biomarkers CCBIO, University of Bergen, Bergen, Norway.
The prognosis for patients with melanoma loco-regional metastases is very heterogenous. Adjuvant PD-L1-inhibitors have improved clinical outcome for this patient group, but the prognostic impact of tumour PD-L1 expression and number of tumour infiltrating lymphocytes (TILs) is still largely unknown. Here, we investigated the impact on survival for CD3, CD8, FOXP3 and PD-L1 TIL counts and tumour PD-L1 expression in melanoma loco-regional metastases.
View Article and Find Full Text PDFNovel genetic insight for psoriasis: integrative genome-wide analyses in 863 080 individuals and proteome-wide Mendelian randomization.
Brief Bioinform
November 2024
Department of Dermatology, Daping Hospital, Army Medical University, No. 10, Changjiang Branch Road, Yuzhong District, Chongqing 400042, China.
Psoriasis affects a significant proportion of the worldwide population and causes an extremely heavy psychological and physical burden. The existing therapeutic schemes have many deficiencies such as limited efficacies and various side effects. Therefore, novel ways of treating psoriasis are urgently needed.
View Article and Find Full Text PDFTreatment of café-au-lait macules with picosecond and nanosecond 1064-nm nd: YAG laser: a retrospective study.
Lasers Med Sci
January 2025
Hospital for Skin Diseases, Shandong First Medical University, Jinan, China.
To investigate the efficacy and safety of picosecond (PS) and nanosecond (NS) 1064-nm neodymium-doped yttrium aluminum garnet (Nd: YAG) laser in treating Café-au-lait macules (CALMs). We retrospectively analyzed the medical records of patients with CALMs, who were treated with PS or NS 1064-nm lasers from January 2020 to January 2022. The efficacy was determined based on the before and after pictures by two independent investigators.
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