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Safety and Efficacy of Initiating Parenteral Nutrition at Home, Home Start PN, in Advanced Peritoneal Metastasis.
Cancers (Basel)
December 2024
Departments of Surgery, Surgical Oncology, University of Nebraska Medical Center, Omaha, NE 68198, USA.
Background: Patients with peritoneal carcinomatosis often experience intestinal failure throughout the course of their disease, and total parenteral nutrition (TPN) can be used as a temporary solution or as a bridge to definitive cytoreductive surgery. Guidelines for TPN are well established for inpatients and in 2014, guidelines were established for the initiation of TPN for outpatients in a home setting. However, the safety and efficacy of home start TPN in advanced oncology patients remain unknown.
View Article and Find Full Text PDFTreatment and Prevention of Adrenal Crisis and Family Education.
J Clin Res Pediatr Endocrinol
December 2024
Baskent University Faculty of Medicine, Department of Pediatric Endocrinology, Adana, Turkey.
Adrenal crisis is a life threatening complication of adrenal insufficiency (AI). Its treatment is urgent and parenteral hydrocortisone should be given at 10-15 times physiological doses in this situation. If hydrocortisone is not available, alternatively prednisolone or methyl prednisolone may be used.
View Article and Find Full Text PDFHow to undertake peripheral intravenous cannulation.
Nurs Stand
December 2024
School of Nursing, Midwifery and Social Work, School of Health and Society, University of Salford, Salford, England.
Peripheral intravenous (IV) cannulation in adults is one of the most commonly performed healthcare procedures. It involves the insertion of a small tube into a vein using a needle, enabling the administration of fluids, blood products and nutrition, and the collection of blood samples. Healthcare professionals performing this procedure must undergo training to be able to undertake it effectively and safely.
View Article and Find Full Text PDFWhat is the role of parenteral nutrition in the management of the patient with severe acute pancreatitis?
Nutr Clin Pract
December 2024
Department of Surgery, Oregon Health Sciences University, Portland, Oregon, USA.
Severe acute pancreatitis often presents as a complex critical illness associated with a high rate of infectious morbidity, multiple organ failure, and in-hospital mortality. Breakdown of gut barrier defenses, dysbiosis of intestinal microbiota, and exaggerated immune responses dictate that early enteral nutrition (EN) is preferred over parenteral nutrition (PN) as the primary route of nutrition therapy. EN, however, is not feasible in all cases because of intolerance, risk of complications, or a direct contraindication to enteral feeding.
View Article and Find Full Text PDFDoes needle clogging change the spatial distribution of injected drug in tissue? New insights by X-ray computed tomography.
Eur J Pharm Biopharm
December 2024
Novartis Pharma AG, WSJ-204/1/100, 4002 Basel, Switzerland.
Prefilled syringes (PFS) are primary packaging materials that offer convenience and safety for subcutaneous injection of parenteral drug solutions. However, an increasingly common problem with the trend towards higher drug concentrations is the clogging of the needle during storage due to evaporative water loss and consequent solidification of the drug. In contrast to all previous studies on this topic, this work focuses on pharmacokinetically relevant aspects and investigates the effects of needle clogging on the spatial distribution of the injected drug in the tissue.
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