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Anti-D Alloimmunization in Index Pregnancy after Appropriate Rho(D) Immune Globulin Injection in Two Obese Rh-Negative Patients.
AJP Rep
July 2024
Department of Maternal Fetal Medicine, Loyola University Medical Center, Illinois.
The rhesus factor D (RhD)-negative patients who give birth to an RhD-positive newborn or who are otherwise exposed to RhD-positive red blood cells are at risk of developing anti-D antibodies. These antibodies may cause hemolytic disease of the fetus and newborn (HDFN). During pregnancy, prevention of alloimmunization is completed with a Rho(D) immune globulin (RhIg).
View Article and Find Full Text PDFGenotyped RhD+ red cells for D-positive patients with sickle cell disease with conventional RHD and unexpected anti-D.
Blood
November 2024
Immunohematology and Genomics Laboratory, New York Blood Center Enterprise, Long Island City, NY.
Anti-D can occur in D-positive patients who inherit RHD genetic variants encoding partial D antigen expression, but unexpected anti-D is also found in the plasma of patients with sickle cell disease who have conventional RHD gene(s) and are transfused with units from Black donors. These anti-D are likely stimulated by variant Rh expressed on donor cells; however, patients with anti-D, regardless of cause, are transfused for a lifetime with D-negative (Rh-negative) blood. This results in significant increased use of Rh-negative units, especially for those requiring chronic transfusion, which can strain Rh-negative blood inventories.
View Article and Find Full Text PDFThe use of free DNA for fetal RHD genotyping in the Rh negative pregnant patient-the time has come.
Am J Obstet Gynecol
August 2024
Department of Women's Health, Dell Medical School - UT Health Austin and the Comprehensive Fetal Center Dell Children's Medical Center, Austin, TX. Electronic address:
Article Synopsis
- Several European countries successfully integrated this method into their routine prenatal care, while it has recently been adopted by two U.S. companies using next-gen sequencing technology.
- With a current shortage of RhoGAM, there’s a push to use these reliable DNA assays in the U.S. to optimize the use of Rhesus immune globulin for RhD-negative pregnant women.
Rh immune globulin immunoprophylaxis after RhD-positive red cell exposure in RhD-negative patients via transfusion: A survey of practices.
Transfusion
May 2024
Department of Pathology and Laboratory Medicine, University of Vermont, Burlington, Vermont, USA.
Background: Current Association for the Advancement of Blood & Biotherapies (AABB) standards require transfusion services to have a policy on Rh immune globulin (RhIG) immunoprophylaxis for when RhD-negative patients are exposed to RhD-positive red cells. This is a survey of AABB-accredited transfusion services in the United States (US) regarding institutional policies and practices on RhIG immunoprophylaxis after RhD-negative patients receive RhD-positive (i.e.
View Article and Find Full Text PDFEffect of Anti-D titers in RhD-negative pregnant women on fetuses and newborns: A retrospective study.
Pediatr Neonatol
May 2024
Department of Pediatrics, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, 510080, China. Electronic address:
Background: Transplacental-derived anti-D IgG in RhD-negative pregnant women can trigger an immune response to Rh D-positive red cells in fetuses and newborns. We assessed the effect of anti-D titers in RhD-negative pregnant women on fetuses and newborns.
Methods: The clinical data of 142 singleton RhD-sensitized pregnancies were retrospectively collected.
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