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Ultrasound-activated erythrocyte membrane-camouflaged Pt (II) layered double hydroxide enhances PD-1 inhibitor efficacy in triple-negative breast cancer through cGAS-STING pathway-mediated immunogenic cell death.
Theranostics
January 2025
Cancer Research Center, School of Medicine, Xiamen University, Xiamen, 361102, China.
Immunogenic cell death (ICD) offers a promising avenue for the treatment of triple-negative breast cancer (TNBC). However, optimizing immune responses remains a formidable challenge. This study presents the design of RBCm@Pt-CoNi layered double hydroxide (RmPLH), an innovative sonosensitizer for sonodynamic therapy (SDT), aimed at enhancing the efficacy of programmed cell death protein 1 (PD-1) inhibitors by inducing robust ICD responses.
View Article and Find Full Text PDFRenal-Clearable Biomass-Derived Carbon Dots with Red Fluorescence for Masked Cryptic Kidney Injury Imaging.
ACS Appl Bio Mater
January 2025
Department of Nephrology, The Second Affiliated Hospital of Shenzhen University, Shenzhen 518101, China.
Masked cryptic kidney injury (MCKI), an early stage of acute kidney injury (AKI), is challenging to detect and diagnose, especially in the modern context where toxic substances, such as surfactants, are increasingly misused. Consequently, there is an urgent need for methods for the visual diagnosis of MCKI. In this study, we synthesized environmentally friendly spirulina-derived carbon dots (SpiCDs) using spirulina as a biobased raw material through a simple hydrothermal process.
View Article and Find Full Text PDFPredicting Risk Factors Affecting the Efficacy of Flexible Ureteral Holmium Laser Lithotripsy and Extracorporeal Shock Wave Lithotripsy for Ureteral Calculi Based on Decision Tree Model.
Ann Ital Chir
January 2025
Department of Urology, Anqing Municipal Hospital, 246003 Anqing, Anhui, China.
Aim: To evaluate the efficacy of flexible ureteroscopic lithotripsy (FURL) and extracorporeal shock wave lithotripsy (ESWL) in the treatment of ureteral calculi based on decision tree model.
Methods: A total of 600 patients with ureteral calculi, including 289 treated with FURL and 311 cases with ESWL in Anqing Municipal Hospital from June 2021 to August 2023, were selected as study subjects. Perioperative indicators and stone clearance rate of the two groups were compared, and the preoperative and postoperative (24 and 72 hours) changes of serum creatinine, cystatin C (Cys-C) and microalbumin were observed.
The Toxoplasma rhoptry protein ROP55 is a major virulence factor that prevents lytic host cell death.
Nat Commun
January 2025
Laboratory of Pathogens and Host Immunity, UMR 5294 CNRS, UA15 INSERM, Université de Montpellier, Montpellier, 34095, France.
Programmed-cell death is an antimicrobial defense mechanism that promotes clearance of intracellular pathogens. Toxoplasma counteracts host immune defenses by secreting effector proteins into host cells; however, how the parasite evades lytic cell death and the effectors involved remain poorly characterized. We identified ROP55, a rhoptry protein that promotes parasite survival by preventing lytic cell death in absence of IFN-γ stimulation.
View Article and Find Full Text PDFDecarboxylase mediated oxalic acid metabolism is important to antioxidation and detoxification rather than pathogenicity in .
Virulence
January 2025
The Key Laboratory for Extreme-Environmental Microbiology, College of Plant Protection, Shenyang Agricultural University, Shenyang, China.
Oxalic acid (OA), an essential pathogenic factor, has been identified in several plant pathogens, and researchers are currently pursuing studies on interference with OA metabolism as a treatment for related diseases. However, the metabolic route in remains unknown. In this study, we describe D-erythroascorbic acid-mediated OA synthesis and its metabolic and clearance pathways in rice blast fungus.
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