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Three New Dipeptide and Two New Polyketide Derivatives from the Mangrove-Derived Fungus sp.: Antioxidant Activity of Two Isolated Substances.
Mar Drugs
December 2024
CAS Key Laboratory of Tropical Marine Bio-resources and Ecology/Guangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China.
Five new metabolites, including three cyclic dipeptide derivatives (-) and two new polyketides (-), together with nine known ones (- and -), were isolated from the mangrove-sediments-derived fungus sp. SCSIO 41431. Their structures were determined using detailed NMR, MS spectroscopic analyses, and quantum chemical calculations.
View Article and Find Full Text PDFBoc-Protected Phenylalanine and Tryptophan-Based Dipeptides: A Broad Spectrum Anti-Bacterial Agent.
Biopolymers
January 2025
Department of Biotechnology, National Institute of Technology Durgapur, Durgapur, West Bengal, India.
Dipeptides were constructed using hydrophobic amino acid residues following AMP prediction. After that Boc-modification was performed on the screened peptides and finally Boc-Phe-Trp-OMe and Boc-Trp-Trp-OMe were synthesized. Even though no inhibition zones were observed in agar well diffusion assays, minimum inhibitory concentration (MIC) analysis revealed anti-bacterial activity against both Gram-positive and Gram-negative bacteria, with MIC ranging from 230 to 400 μg/mL.
View Article and Find Full Text PDFFmoc-Pro-Phe-OMe dipeptide carbon sensor for simultaneous detection of chloramphenicol (CP) and furazolidone (FZ) toxic residues in food samples.
J Environ Sci Health B
January 2025
Department of Chemistry, B.M.S. College of Engineering, Bengaluru, Karnataka, India.
In this work, we fabricated the Fmoc-Pro-Phe-OMe modified carbon paste electrode (FPPO/MCPE) and used it for electrochemical detection of CP and FZ in a 0.1 M phosphate buffer solution (pH = 7). We characterized the Fmoc-Pro-Phe-OMe and applied it for the electrochemical detection of CP and FZ.
View Article and Find Full Text PDFWhy Bestatin Prefers Human Carnosinase 2 (CN2) to Human Carnosinase 1 (CN1).
J Phys Chem B
December 2024
Department of Chemistry, Faculty of Science, Kasetsart University, Chatuchak, Bangkok 10900, Thailand.
Human carnosinases (CNs) are Xaa-His metal-ion-activated aminopeptidases that break down bioactive carnosine and other histidine-containing dipeptides. Carnosine is a bioactive peptide found in meat and prevalently used as a supplement and in functional food formulation. Nonetheless, carnosine is digested by CNs rapidly after ingestion.
View Article and Find Full Text PDFNiacin-Cholic Acid-Peptide Conjugate Act as a Potential Antibiotic Adjuvant to Mitigate Polymicrobial Infections Caused by Gram-Negative Pathogens.
ACS Infect Dis
December 2024
Laboratory of Nanotechnology and Chemical Biology, Regional Centre for Biotechnology, Third Milestone, Faridabad-Gurgaon Expressway, NCR Biotech Cluster, Faridabad 121001, Haryana, India.
Article Synopsis
- Polymicrobial wound infections caused by Gram-negative bacteria are difficult to treat with standard antibiotics, prompting the exploration of using adjuvants to enhance their effectiveness.
- A niacin-cholic acid-peptide conjugate was developed to improve the action of macrolide antibiotics like erythromycin against these stubborn bacterial infections.
- The study found that this conjugate helps disrupt bacterial membranes, allowing erythromycin to enter more effectively, ultimately showing success in eliminating both single and mixed bacterial infections associated with wounds.
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