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Commissioning of the Varian universal interstitial cylinder system for HDR brachytherapy of gynecological cancer.
J Appl Clin Med Phys
December 2024
Department of Radiation Oncology, Duke University, Durham, North Carolina, USA.
Purpose: This paper outlines the commissioning of the Varian (VMS, Varian Medical Systems, Palo Alto, CA) Universal Interstitial Cylinder (UIC) applicator set for Ir-192 HDR brachytherapy. The UIC was commissioned for use with CT and MRI and a custom phantom was designed to avoid the introduction of water-like materials into the needle guide tracks. Various marker strands were investigated to determine which allowed the most accurate reconstruction of source positions.
View Article and Find Full Text PDFDevelopment of a novel radioiodinated compound for amyloid and tau deposition imaging in Alzheimer's disease and tauopathy mouse models.
Neuroimage
December 2024
Department of Radiopharmacy and Molecular Imaging, Minhang Hospital & School of Pharmacy, Fudan University, Shanghai, China; Department of Functional Brain Imaging Research, China; Department of Clinical and Experimental Neuroimaging, Centre for Development of Advanced Medicine for Dementia, National Centre for Geriatrics and Gerontology, Obu, Japan; Key Laboratory of Smart Drug Delivery, Fudan University, Ministry of Education, Shanghai, China; Institute for Small-Molecule Drug Discovery & Development, Quzhou Fudan Institute, Quzhou, China. Electronic address:
Article Synopsis
- - The study focused on a new compound called AD-DRK (I-AD-DRK) that can non-invasively identify amyloid-β and tau deposits in the brain, which are critical for diagnosing Alzheimer's disease and related disorders.
- - Researchers conducted tests using this compound in both postmortem human brains and mouse models with amyloid and tau accumulation, demonstrating its effective binding and visualization capabilities in the brain regions associated with these proteins.
- - The results showed that I-AD-DRK has strong potential as a SPECT imaging agent, offering high-contrast imaging of amyloid and tau, which could significantly help in early diagnosis and treatment of Alzheimer's disease and other tauopathies.
PAR-dCLIP: Enabling detection of RNA binding protein target transcripts bound at 5' termini through the incorporation of a decapping step.
Methods Enzymol
October 2024
Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN, United States; Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN, United States. Electronic address:
RNA binding proteins (RBPs) are responsible for facilitating a wealth of post-transcriptional gene regulatory functions. The role of an RBP on regulated transcripts can be investigated through a pull-down of the RBP and high-throughput sequencing (HTS) of the associated transcripts. Photoactivatable Ribonucleoside-Enhanced Crosslinking and Immunoprecipitation (PAR-CLIP), is one such pull-down method that isolates, detects, and sequences the cDNA of RBP-associated transcripts.
View Article and Find Full Text PDFF-ASEM PET/MRI targeting alpha7-nicotinic acetylcholine receptor can reveal skeletal muscle denervation.
EJNMMI Res
January 2024
Convergence Medicine Research Center, Asan Institute for Life Sciences, Asan Medical Center, Seoul, Republic of Korea.
Article Synopsis
- The study investigates the increased expression of nicotinic acetylcholine receptors (nAChR) in muscles after nerve injury, focusing on the F-ASEM radiotracer as a diagnostic tool for visualizing muscle denervation in mice following sciatic nerve resection.
- Mice were evaluated at one and three weeks post-denervation using F-ASEM PET/MRI imaging, measuring the uptake in the affected muscles compared to the control side, with results indicating significantly higher uptake in denervated muscles.
- Additional analyses, including autoradiography and immunohistochemistry, confirmed increased alpha7-nAChR expression in denervated muscles, while a blocking study indicated that when blocked, the F-ASEM
Autoradiographic characterization of [ F]PSMA-1007 binding in rat brain.
Synapse
November 2023
Department of Nuclear Medicine, Bern University Hospital, Bern, Switzerland.
Carboxypeptidase II (CBPII) in brain metabolizes the neuroactive substance N-acetyl-L-aspartyl-L-glutamate (NAGG) to yield the elements of glutamate and N-acetyl-aspartate (NAA). In peripheral organs, CBPII is known as prostrate specific membrane antigen (PSMA), which presents an important target for nuclear medicine imaging in prostate cancer. Available PSMA ligands for PET imaging do not cross the blood-brain barrier, and there is scant knowledge of the neurobiology of CBPII, despite its implication in the regulation of glutamatergic neurotransmission.
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