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Syphilis is a sexually transmitted infection caused by the spirochete (TP) subspecies . Syphilis can be transmitted via contact with infected bodily fluids, such as blood or semen, congenital infection, blood transfusion, or organ transplantation. After a brief incubation period, the disease manifests with signs and symptoms such as genital ulcers, erythematous papules on the palms and soles, fever, and lymphadenopathy.

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We report a case of syphilitic balanitis of Follmann arising in a man with a history of prior infection with syphilis. Few cases have been described in the literature. In our case, a man with history of multiple unprotected sexual contacts presented with erosive balanitis and painless inguinal bilateral lymphadenopathy.

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Objectives: The range of histopathologic features of gastric syphilis is not well described. Here we describe the clinicopathologic findings of eight patients with syphilitic gastritis.

Methods: A search of our Pathology Data System (2003-2022) and multiple other institutions identified eight patients with syphilitic gastritis.

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Rationale: Diagnosing multifactorial, multidimensional symptoms unexplained by presumptive diagnosis is often challenging for infectious disease specialists.

Patient Concerns: We report a rare case of a 30-year-old Japanese bisexual man with a history of virally suppressed human immunodeficiency virus and syphilis infections who developed chest pain and an erosive lesion under the lower midline jaw.

Diagnosis: Imaging examinations revealed erosive lesions on the sternum and left the ninth rib.

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