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Genome-wide association studies (GWAS) have identified genetic variants robustly associated with asthma. A potential near-term clinical application is to calculate polygenic risk score (PRS) to improve disease risk prediction. The value of PRS, as part of numerous multi-source variables used to define asthma, remains unclear.
View Article and Find Full Text PDFThe association between type 2 diabetes and asthma incidence: a longitudinal analysis considering genetic susceptibility.
BMC Public Health
January 2025
Department of Endocrinology, China-Japan Friendship Hospital, No.2 Yinghuayuan East Street, Hepingli, Chaoyang District, 100029, Beijing, China.
Background: The prevalence of type 2 diabetes (T2D) and asthma is rising, yet evidence regarding the relationship between T2D and asthma, particularly in the context of genetic predispositions, remains limited.
Methods: This study utilized data from the UK Biobank longitudinal cohort, involving 388,775 participants. A polygenic risk score (PRS) for asthma was derived from genome-wide association studies summary.
Routine use of genetic data in healthcare is much-discussed, yet little is known about its performance in epidemiological models including traditional risk factors. Using severe COVID-19 as an exemplar, we explore the integration of polygenic risk scores (PRS) into disease models alongside sociodemographic and clinical variables. PRS were optimized for 23 clinical variables and related traits previously-associated with severe COVID-19 in up to 450,449 UK Biobank participants, and tested in 9,560 individuals diagnosed in the pre-vaccination era.
View Article and Find Full Text PDFVPS13D-related disorders: a severe case, review, and genotype-phenotype correlation.
Neurocase
January 2025
Department of Ophthalmology, Affiliated Hospital of Guizhou Medical University, Guiyang, P.R. China.
Background: -related disorders are autosomal recessive genetic disorders characterized by movement disorders primarily including ataxia and spasticity, mainly accompanying developmental delay, seizures, and neuroimaging abnormalities. -related spectrum disorder (VSD) may better reflect the characteristics of the disease. So far, the relationship of genotype and phenotype of VSD has not been established.
View Article and Find Full Text PDFEncapsulation of astilbin in zein nanoparticles with fructo-oligosaccharides and caseinate as costabilizers: Formation, stability, bioavailability, and antioxidant capacity.
Int J Biol Macromol
January 2025
National Engineering Institute for the Research and Development of Endangered Medicinal Resources in Southwest China, Guangxi Botanical Garden of Medicinal Plants, Nanning 530023, China; Guangxi Key Laboratory of High-Quality Formation and Utilization of Dao-Di Herbs, National Center for TCM Inheritance and Innovation, Guangxi Botanical Garden of Medicinal Plants, Nanning 530023, China. Electronic address:
Zein-based nanoparticles (NPs) have attracted considerable attention as potential delivery systems for bioactive compounds. However, their application has been limited by poor stability and redispersibility. In this study, we addressed these challenges by fabricating zein nanocarriers using branching structural fructo-oligosaccharides (P-FOS) and sodium caseinate (NaCas) as costabilizers.
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