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Seasonal trends of pyogenic spondylodiscitis in Japan: a nationwide inpatient database study.
Int J Infect Dis
December 2024
Department of Orthopedic Surgery, Tokyo Medical and Dental University, Tokyo, Japan.
Objectives: The aims of this study were 1) to investigate seasonal epidemiological variations of pyogenic spondylodiscitis, including Methicillin-resistant Staphylococcus aureus (MRSA) infection, in Japan, and 2) to evaluate associated inpatient outcomes.
Methods: We performed a retrospective nationwide study using data from the Japanese Diagnosis Procedure Combination (DPC) inpatient database, covering the period from 2010 to 2022. The parameters assessed were seasonal incidence, demographic characteristics, inpatient mortality, complications, and medical costs.
Citrobacter youngae nosocomial bacteremia from postoperative pyogenic spondylodiscitis after a minimally invasive spinal surgery.
BMC Infect Dis
December 2024
108 Military Central Hospital, Vietnamese - German Center for Medical Research (VG-CARE), N 1, Tran Hung Dao Str., Hai Ba Trung Dist, Hanoi, 1000, Vietnam.
Citrobacter youngae (C. youngae) was first described in 1993, and data suggesting that human diseases caused by this bacterium remain scarce. Reports on C.
View Article and Find Full Text PDFManagement of severe pyogenic spinal infections: the 2SICK study by the EANS spine section.
Spine J
December 2024
Department of Neurosurgery, University Medical Center Mainz, Mainz, Germany.
Background Context: Spondylodiscitis management presents significant clinical challenges, particularly in critically ill patients, where the risks and benefits of surgical intervention must be carefully balanced. The optimal timing of surgery in this context remains a subject of debate.
Purpose: This study aims to evaluate the effectiveness of early surgery versus delayed surgery or conservative management in critically ill patients with de novo pyogenic spondylodiscitis.
Current knowledge of vertebral osteomyelitis: a review.
Eur J Clin Microbiol Infect Dis
February 2025
Department of Orthopedic Surgery, China-Japan Union Hospital, Jilin University, Jilin, 130033, China.
Article Synopsis
- The increasing elderly population worldwide has heightened the need for understanding vertebral osteomyelitis, which involves a comprehensive review of its microbiology, clinical signs, diagnostics, and treatment options.
- Research identified common bacterial causes, like Staphylococcus aureus, and noted the condition often presents with non-specific symptoms, making early diagnosis challenging.
- Effective treatment necessitates quick diagnosis and targeting the specific pathogen, with surgical options available for severe cases to prevent severe complications like neurological damage or death.
TLR4 and TNF-α single nucleotide polymorphisms in patients with brucellosis: Association with infection complications.
Eur J Intern Med
January 2025
Department of Medicine and Research Laboratory of Internal Medicine, National Expertise Centre of Greece in Autoimmune Liver Diseases, General University Hospital of Larissa, Larissa 41110, Greece.
Objectives: To investigate associations of the carriage of single nucleotide polymorphisms (SNPs) of proteins involved in the immune response of patients with brucellosis.
Methods: A case control study of patients with brucellosis upon WHO criteria. Blood genomic analysis was performed by RFLP- PCR for the detection of SNPs: i) at promoters -376 G > A (rs1800750); -308 G > A (rs 1,800,629); -238 G > A (rs361525) of the TNF gene, ii) at -896 A > G Asp299Gly (rs4986790) and -1196 C > T Thr399Ile (rs4986791) positions of the TLR-4 gene.
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