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Comparison of the ED50 of prophylactic butorphanol in preventing morphine-induced pruritus with or without palonosetron: a prospective, double-blinded, randomized dose-response trial using an up-down sequential allocation method.
Ann Med
January 2024
Department of Anesthesiology, Women's Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
Article Synopsis
- Butorphanol is used to alleviate itching caused by morphine during epidural anesthesia, and palonosetron is a popular anti-nausea medication.
- The study involved 120 participants divided into two groups: one receiving both palonosetron and butorphanol, and the other receiving only butorphanol, to evaluate the effectiveness of preventing itching from morphine.
- Results showed that the combination of palonosetron and butorphanol significantly reduced the effective dose needed to prevent itching by about 8%, indicating that palonosetron enhances the effectiveness of butorphanol for this purpose.
The median effective dose of propofol combined with butorphanol during artificial abortion: a randomized controlled trial.
Front Med (Lausanne)
November 2023
Department of Anesthesiology, The Affiliated Shunde Hospital of Jinan University, Foshan, China.
Objective: Propofol-opioids are the most common drug combination and can reduce the dose of propofol and the incidence of adverse events in painless artificial abortion. We hypothesized that butorphanol may reduce the median effective dose (ED) of propofol, propofol injection pain, and postoperative uterine contraction pain.
Methods: This was a randomized, double-blind, controlled study.
Effect of butorphanol-soaked nasal packing after endoscopic nasal surgery: a double-blind, randomized, placebo-controlled trial.
Braz J Otorhinolaryngol
January 2024
The First Affiliated Hospital of Shantou University Medical College, Department of Anesthesiology, Shantou City, Guangdong Province, China. Electronic address:
Objective: This study was designed to investigate the effect of butorphanol-soaked nasal packing on analgesia and sleep quality in patients undergoing bilateral endoscopic nasal surgery.
Methods: Sixty-six patients were enrolled and randomly allocated into three groups: group B1 (butorphanol 0.03mg/kg), group B2 (butorphanol 0.
Comparative assessment of dexmedetomidine and butorphanol for attenuation of etomidate-induced myoclonus: A double-blind, randomised controlled study.
Indian J Anaesth
September 2023
Department of Anaesthesiology and Critical Care, University College of Medical Sciences and GTB Hospital, Delhi, India.
Background And Aims: Etomidate is a popular induction agent, but its use is associated with myoclonus in 50%-80% of non-premedicated patients. This study aims to compare dexmedetomidine and butorphanol for their relative efficacy in preventing etomidate-induced myoclonus.
Methods: This randomised study was conducted after obtaining institutional ethical committee clearance and written informed consent from sixty American Society of Anesthesiologists (ASA) I or II consenting patients between 18 and 60 years of age of either sex who had been scheduled for elective surgeries under general anaesthesia.
Pre-emptive infiltration with betamethasone and ropivacaine for postoperative pain in laminoplasty and laminectomy (PRE-EASE): a prospective randomized controlled trial.
Int J Surg
January 2024
Department of Pain Management.
Background: Postoperative pain after laminoplasty and laminectomy occurs partially from local trauma of the paraspinal tissue. Finding a multimodal analgesic cocktail to enhance the duration and effect of local infiltration analgesia is crucial. Because of the rapid onset and long duration of action of betamethasone, the authors hypothesized that, a pre-emptive multimodal infiltration regimen of betamethasone and ropivacaine reduces pain scores and opioid demand, and improves patient satisfaction following laminoplasty and laminectomy.
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