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Single-Atom Cu Anchored on Carbon Nitride as a Bifunctional Glucose Oxidase and Peroxidase Nanozyme for Antibacterial Therapy.
ACS Nano
March 2025
Translational Medicine Laboratory, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325035, China.
A very promising strategy to avoid bacterial drug resistance is to replace antibiotics with artificial nanozymes, but this has not yet been translated to the clinic. Here, we construct a single-atom nanozyme using graphitic carbon nitride nanosheets modified by copper (Cu--CN). This Cu--CN nanosheet possesses both glucose oxidase-like and peroxidase-like activities responsible for reactive-oxygen-species generation by a cascade reaction to eradicate Gram-positive and Gram-negative multidrug-resistant bacteria.
View Article and Find Full Text PDFCorrelation between changes in apathy and cognition in Alzheimer's disease associated apathy: Analysis of the Apathy in Dementia Methylphenidate Trial 2 (ADMET 2).
Int Psychogeriatr
March 2025
Sunnybrook Research Institute, University of Toronto, Toronto, ON, Canada; Department of Psychiatry, University of Toronto, Toronto, ON, Canada. Electronic address:
Background: Previous trials have shown improvements in both apathy and cognition with methylphenidate (MPH).
Objectives: To assess whether changes in apathy correlated with changes in cognition in the Apathy in Dementia Methylphenidate Trial 2 (ADMET 2).
Participants: Mild to moderate AD patients with clinically significant apathy randomized to MPH (20 mg/day) or placebo for 6 months.
Validation of the GPAT - the Global Polypectomy Assessment Tool: European Society of Gastrointestinal Endoscopy (ESGE) Position Statement.
Endoscopy
March 2025
Department of Gastroenterology, Faculty of Medicine and Health Sciences, University of Ghent, Ghent, Belgium.
BACKGROUND : Colorectal polypectomy is operator dependent, with variable rates of complete resection. The currently available assessment tools do not provide specific competency-based evaluation of provider technique. We aimed to validate the Global Polypectomy Assessment Tool (GPAT), a novel competency assessment tool for colorectal polypectomy.
View Article and Find Full Text PDFEvaluation of morphological and chemical composition of dental pulp stones: a combined microanalytical approach.
J Endod
March 2025
Department of Clinical Sciences and Stomatology (DISCO), Università Politecnica, delle Marche, 60126 Ancona, Italy.
Introduction: Pulp stones (PS) are mineralized ectopic structures within the dental pulp that vary in morphology, composition, and location. Their etiology remains uncertain and poses clinical challenges in endodontics. This study hypothesized that combined analytical techniques would enhance understanding of PS morphology and composition, facilitating improved clinical management of complex cases.
View Article and Find Full Text PDFIdentification of functional biomarkers for personalized nanomedicine in advanced breast cancer in vitro models.
J Control Release
March 2025
Polymer Therapeutics Lab, Centro de Investigación Príncipe Felipe, Av. Eduardo Primo Yúfera 3, Valencia 46012, Spain; Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), ISCCIII, Madrid, Spain. Electronic address:
Nanomedicines represent promising advanced therapeutics for the enhanced treatment of breast cancer, the primary cause of cancer-related deaths in women; however, the clinical translation of nanomedicines remains challenging. Advanced in vitro models of breast cancer may improve preclinical evaluations and the identification of biomarkers that aid the stratification of patients who would benefit from a given nanomedicine. In this study, we first developed a matrix-embedded breast cancer cell spheroid model representing the extracellular matrix and confirmed the faithful recapitulation of disease aggressiveness in vitro.
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