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Evaluation of the anti-snakebite, antimicrobial and antioxidant potential of Philodendron megalophyllum Schott (Araceae), traditionally used in accidents caused by snakes in the western region of Pará, Brazil.
Toxicon
September 2020
Programa de Pós-graduação Em Recursos Naturais da Amazônia - PPGRNA, Laboratório de Bioprospecção e Biologia Experimental -LabBBEx, Universidade Federal Do Oeste Do Pará- UFOPA, Santarém, PA, Brazil. Electronic address:
Ethnopharmacological Relevance: In the region of Western Pará, Amazonia, Brazil, Philodendron megalophyllum is widely used for the treatment of envenomations caused by bites from venomous snakes. The traditional use of plants is usually done through oral administration of an infusion (decoction) soon after the bite occurs. The efficiency of aqueous extracts of P.
View Article and Find Full Text PDFEvaluating the effects of anticoagulants on Rhodnius prolixus artificial blood feeding.
PLoS One
April 2019
Instituto de Bioquímica Médica Leopoldo de Meis, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Rio de Janeiro, Brazil.
Blood-sucking insects are responsible for the transmission of several important disease-causing organisms such as viruses, bacteria, and protozoans. The hematophagous hemipteran Rhodnius prolixus is one of the most important vectors of Trypanosoma cruzi, the etiological agent of Chagas disease. Due to the medical importance of this insect, it has been used as a study model in physiology and biochemistry since the 1930s.
View Article and Find Full Text PDFA New Platelet-Aggregation-Inhibiting Factor Isolated from Snake Venom.
Biomed Res Int
July 2018
Instituto Nacional de Ciência e Tecnologia em Nano-Biofarmacêutica (N-Biofar), Belo Horizonte, MG, Brazil.
This work reports the purification and functional characterization of BmooPAi, a platelet-aggregation-inhibiting factor from snake venom. The toxin was purified by a combination of three chromatographic steps (ion-exchange on DEAE-Sephacel, molecular exclusion on Sephadex G-75, and affinity chromatography on HiTrap™ Heparin HP). BmooPAi was found to be a single-chain protein with an apparent molecular mass of 32 kDa on 14% SDS-PAGE, under reducing conditions.
View Article and Find Full Text PDFAssessment of the anti-snakebite properties of extracts of Aniba fragrans Ducke (Lauraceae) used in folk medicine as complementary treatment in cases of envenomation by Bothrops atrox.
J Ethnopharmacol
March 2018
Programa de Pós-graduação em Recursos Naturais da Amazônia-PPGRNA, Universidade Federal do Oeste do Pará- UFOPA, Santarém, PA, Brazil; Universidade Federal do Oeste do Pará- UFOPA, Laboratório de Bioprospecção e Biologia Experimental -LabBBEx, Santarém, PA, Brazil. Electronic address:
Ethnopharmacological Relevance: Extracts of leaves and bark of Aniba fragrans are used as tea (decoction) to treat snakebites in communities in the Brazilian Amazon. The aqueous extract of the leaves of A. fragrans has been proven to be effective against Bothrops venom, but only when pre-incubated with the venom.
View Article and Find Full Text PDFThe potential of aqueous extracts of Bellucia dichotoma Cogn. (Melastomataceae) to inhibit the biological activities of Bothrops atrox venom: A comparison of specimens collected in the states of Pará and Amazonas, Brazil.
J Ethnopharmacol
January 2017
Programa Multi-institucional de Pós-graduação em Biotecnologia, Instituto de Ciências Biológicas, Universidade Federal do Amazonas, Manaus, AM, Brazil; Laboratório de Imunoquímica, Departamento de Parasitologia, Instituto de Ciências Biológicas, Universidade Federal do Amazonas, Manaus, AM, Brazil.
Ethnopharmacological Importance: The effectiveness of aqueous extract of Bellucia dichotoma Cogn. (Melastomataceae) specimems collected in Santarém, PA, against some biological activities of Bothrops atrox venom (BaV) has been scientifically proven. Here, we analyzed the components and assessed the anti-snakebite potential of aqueous extracts of bark of B.
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