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Therapeutic efficacy and short-term durability of trans-urethral amniotic bladder injections for the treatment of refractory COVID-associated cystitis.
Bladder (San Franc)
October 2024
John D. Dingell VA Medical Center, Detroit, Michigan, United States of America.
Introduction: COVID-19-associated cystitis (CAC) may arise following a COVID-19 infection and is characterized by the development of novel or worsening overactive bladder (OAB). CAC is possibly associated with bladder mucosal damage and the release of pro-inflammatory cytokines, resulting in inflammation and fibrosis of the bladder wall. Amniotic membrane (AM) has been shown to possess anti-inflammatory and anti-fibrotic properties and might potentially be beneficial for CAC.
View Article and Find Full Text PDFBotulinum toxin A for the treatment of neurogenic bladder in children: a systematic review and meta-analysis.
ANZ J Surg
November 2024
Department of Pediatric Surgery, Hangzhou Children's Hospital, Hangzhou, Zhejiang, China.
Article Synopsis
- A systematic review and meta-analysis were conducted to evaluate the efficacy of botulinum toxin A (BTX-A) injections in children with neurogenic bladder (NB) who do not respond to traditional antimuscarinic treatments.
- The review examined 19 studies, highlighting significant improvements, such as a 97.7 mL increase in cystometric capacity, a decrease in detrusor pressure by 25.2 cm HO, and a 73.4% incontinence resolution rate post-treatment.
- However, the studies varied in quality and design, lacking a placebo comparison and control groups, indicating that the evidence for BTX-A's effectiveness is not firmly established.
Prevalence and risk factors for overactive bladder symptoms in patients with artificial urinary sphincter.
Sci Rep
September 2024
Department of Urology and Andrology, Kansai Medical University, 2-3-1 Shin-machi, Hirakata, Osaka, 573-1191, Japan.
To demonstrate the prevalence and risk factors for overactive bladder symptoms associated with artificial urinary sphincter implantation, we investigated the patients who underwent primary artificial urinary sphincter implantation with severe urinary stress incontinence. Forty-eight patients who completely answered the questionnaires of the overactive bladder symptom score before surgery were included. Patient characteristics, urinary status at pre and 1, 3, 6, and 12 months post-device activation, and predictive factors for overactive bladder symptoms were examined.
View Article and Find Full Text PDFA randomized controlled trial of low-frequency repeated transcranial magnetic stimulation in patients with poststroke neurogenic bladder.
Sci Rep
August 2024
Department of Rehabilitation Medicine, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, 400010, China.
Urinary incontinence is a common complication in stroke survivors for whom new interventions are needed. This study investigated the therapeutic effect of low-frequency (LF) repeated transcranial magnetic stimulation (rTMS) on the contralesional primary motor cortex (M1) in patients with poststroke urinary incontinence (PSI). A total of 100 patients were randomly assigned to the rTMS group or sham-rTMS group on basis of the intervention they received.
View Article and Find Full Text PDFTranscutaneous neuromodulation versus oxybutynin for neurogenic detrusor overactivity in persons with spinal cord injury: A randomized, investigator blinded, parallel group, non-inferiority controlled trial.
J Spinal Cord Med
July 2024
Department of Physical Medicine and Rehabilitation, Mahatma Gandhi Medical College and Hospitals, Jaipur, Rajasthan, India.
Study Design: This study is a randomized, investigator-blinded, controlled trial with a non-inferiority design.
Objective: To investigate the effectiveness of neuromodulation by transcutaneous electrical stimulation of the somatic afferent nerves of the foot in neurogenic detrusor overactivity (NDO) in persons with spinal cord injury (SCI) and compare its effectiveness with oral oxybutynin.
Setting: The study was conducted in a rehabilitation in-patient ward of a tertiary care hospital.
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