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Effect of Elderberry ( L.) Extract Intake on Normalizing Testosterone Concentration in Testosterone Deficiency Syndrome Rat Model Through Regulation of 17β-HSD, 5α-Reductase, and CYP19A1 Expression.
Nutrients
November 2024
College of Pharmacy, Sahmyook University, Seoul 01795, Republic of Korea.
Men experience Leydig cell and mitochondrial dysfunction due to the accumulation of reactive oxygen species during aging, leading to hormonal imbalances in the body. This results in symptoms of testosterone deficiency syndrome (TDS) as testosterone levels decline. Consequently, there is a growing need for alternative therapies, such as phytotherapy, to regulate testosterone secretion.
View Article and Find Full Text PDFMultiomics identification of programmed cell death-related characteristics for nonobstructive azoospermia based on a 675-combination machine learning computational framework.
Genomics
December 2024
Center for Reproductive Medicine, the Affiliated Qingyuan Hospital (Qingyuan People's Hospital), Guangzhou Medical University, Qingyuan, Guangdong 511518, China; Guangdong Engineering Technology Research Center of Urinary Continence and Reproductive Medicine, the Affiliated Qingyuan Hospital (Qingyuan People's Hospital), Guangzhou Medical University, Qingyuan, Guangdong 511518, China. Electronic address:
Background: Abnormal programmed cell death (PCD) plays a central role in spermatogenic dysfunction. However, the molecular mechanisms and biomarkers of PCD in patients with nonobstructive azoospermia (NOA) remain unclear.
Methods: The genetic conditions of NOA patients were analysed using bulk transcriptomic, single-cell transcriptomic, single nucleotide polymorphism (SNP), and clinical data from multiple centres.
Pathogenesis of testicular dysfunction in diabetes: exploring the mechanism and therapeutic interventions.
J Assist Reprod Genet
December 2024
Department of Physiology, Kampala International University, Western Campus, Ishaka, Uganda.
Diabetes mellitus is a global epidemic contributing to the rising male infertility rates. Addressing testicular dysfunction in diabetic patients requires a multimodal strategy encompassing medication, lifestyle changes, early diagnosis, and innovative treatments targeting specific biochemical pathways. This review explores the mechanisms of diabetes-induced testicular dysfunction and potential intervention targets.
View Article and Find Full Text PDF[Ovarian collision tumor with postmenopausal hyperandrogenism: a case report].
Zhonghua Nei Ke Za Zhi
December 2024
Department of Endocrinology, the First Medical Center, Chinese PLA General Hospital, Beijing100039, China.
Pure Leydig cell tumor of the ovary: a rare presentation of a rare entity in a pregnant patient.
Future Sci OA
December 2024
Pathology department, King Abdullah University Hospital, Jordan university of science and technology, Irbid, Jordan.
Leydig cell tumors (LCT) are rare neoplasms that represent less than 0.1% of all ovarian tumors. This tumor usually presents with signs and symptoms of excess androgen levels.
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