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Efficacy and safety of azathioprine in patients with Cronkhite-Canada syndrome: a case series from Peking Union Medical College Hospital.
BMC Pharmacol Toxicol
December 2024
Department of Gastroenterology, Chinese Academy of Medical Sciences, Peking Union Medical College Hospital, No.1 Shuaifuyuan Wangfujing Dongcheng District, Beijing, 100730, China.
Background: Cronkhite-Canada syndrome (CCS) is a rare non-hereditary chronic inflammatory disease characteristic of gastrointestinal polyps and ectodermal abnormalities. Corticosteroid therapy is the mainstay medication for CCS. Few studies indicated immunosuppressants might be the choices for patients with steroid refractory, steroid dependent or intolerant.
View Article and Find Full Text PDFPuestow surgery in a SPINK mutation chronic pancreatitis: a rare case report.
J Surg Case Rep
October 2024
Department of General Surgery, Santa Casa de Misericórdia de Porto Alegre, Porto Alegre, Brazil.
Article Synopsis
- - A 27-year-old man with recurrent pancreatitis was found to have a rare genetic mutation (homozygous SPINK1 N34S) after multiple hospitalizations and diagnostic testing.
- - After unsuccessful endoscopic treatments, he underwent a laparoscopic Puestow procedure to improve his symptoms and pancreatic drainage.
- - His recovery was successful, and he was discharged with enzyme therapy, highlighting the complexities of diagnosing and managing hereditary pancreatitis linked to genetic factors.
Non-Hereditary Obesity Type Networks and New Drug Targets: An In Silico Approach.
Int J Mol Sci
July 2024
Clinical, Translational Research and Experimental Surgery Centre, Biomedical Research Foundation of the Academy of Athens, 4, Soranou Ephessiou Str., 11527 Athens, Greece.
Obesity, a chronic, preventable disease, has significant comorbidities that are associated with a great human and financial cost for society. The aim of the present work is to reconstruct the interactomes of non-hereditary obesity to highlight recent advances of its pathogenesis, and discover potential therapeutic targets. Obesity and biological-clock-related genes and/or gene products were extracted from the biomedical literature databases PubMed, GeneCards and OMIM.
View Article and Find Full Text PDFA case of membranous nephropathy complicated by Cronkhite-Canada syndrome successfully treated with mizoribine.
CEN Case Rep
July 2024
Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-Cho, Okayama, 700-8558, Japan.
Cronkhite-Canada syndrome (CCS) is a non-hereditary disorder characterized by non-neoplastic hamartomatous gastrointestinal polyposis, hair loss, nail atrophy, hyperpigmentation, and diarrhea. While the relationship between CCS and nephritis remains unclear, seven cases of nephritis complicated by CCS have been reported to date, all of which were membranous nephropathy (MN). A 57-year-old man presented with taste disturbance, hair loss, nail plate atrophy, skin pigmentation, and frequent diarrhea.
View Article and Find Full Text PDFMachine learning-based health environmental-clinical risk scores in European children.
Commun Med (Lond)
May 2024
ISGlobal, Barcelona, Spain.
Background: Early life environmental stressors play an important role in the development of multiple chronic disorders. Previous studies that used environmental risk scores (ERS) to assess the cumulative impact of environmental exposures on health are limited by the diversity of exposures included, especially for early life determinants. We used machine learning methods to build early life exposome risk scores for three health outcomes using environmental, molecular, and clinical data.
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