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Background: Acne is an inflammatory skin disease afflicting the majority of the world's population at some point in their lifetime, and is seen to be chronic in about 50% of cases. Acne leads to significant social withdrawal, depression, and disfiguring scars in many cases. Available treatments are characterized by high rates of relapse, dangerous side effects, and social stigma, which often leads to poor patient compliance and treatment failure.
View Article and Find Full Text PDFCRISPR/Cas9-mediated genomic insertion of functional genes into WCFS1.
Microbiol Spectr
January 2025
Faculty of Chemistry, Biotechnology and Food Science, NMBU - Norwegian University of Life Sciences, Ås, Norway.
Unlabelled: a natural inhabitant of the human body, is a promising candidate vehicle for vaccine delivery. An obstacle in developing bacterial delivery vehicles is generating a production strain that lacks antibiotic resistance genes and contains minimal foreign DNA. To deal with this obstacle, we have constructed a finetuned, inducible two-plasmid CRISPR/Cas9-system for chromosomal gene insertion in .
View Article and Find Full Text PDFOutcomes after Ventral Hernia Repair with Concurrent Panniculectomy: A Large Database Review.
J Am Coll Surg
January 2025
Department of Surgery, New Hanover Regional Medical Center, Novant Health, Wilmington, NC.
Background: Patients with large pannus and ventral hernias may benefit from undergoing panniculectomy performed concurrently with open ventral hernia repair (VHR-PAN). However, there has been concerns related to increase surgical site occurrences when adding a panniculectomy. This study aims to evaluate outcomes of open VHR with and without panniculectomy using a large hernia specific database.
View Article and Find Full Text PDFIdentification and treatment of false methane values produced by the tunable diode laser absorption spectroscopy technology equipped on unmanned aerial vehicles.
Integr Environ Assess Manag
January 2025
Ionian Department, University of Bari Aldo Moro, Bari, Italy.
Fugitive or diffuse methane emissions constitute an important source of damage to the environment, much greater even than CO2 both over a time span of 20 years and over a longer time span of 100. It is therefore of preeminent importance to undertake all the efforts necessary to implement new tools, protocols, and methods that contribute to the identification and measurement of these emissions to implement site-specific actions of mitigation, repair, and conscious management of the emitting plants. Among the remote sensing and leak detection technologies currently used, the tunable diode laser absorption spectroscopy (TDLAS) method plays a relevant role.
View Article and Find Full Text PDFQuality of life assessment after minimally invasive operative treatment in children with pectus excavatum: A single-center study and literature review.
Adv Clin Exp Med
January 2025
Department of Pediatric Surgery, Antoni Jurasz University Hospital No. 1, Faculty of Medicine, Ludwik Rydygier Medical College in Bydgoszcz, Nicolaus Copernicus University in Toruń, Poland.
Background: Most patients with chest wall deformities have a negative body image, which affects their self-esteem and quality of life (QoL).
Objectives: The aim of this study was to evaluate changes in patients' QoL after minimally invasive repair of pectus excavatum (MIRPE).
Material And Methods: A prospective, single-center study was conducted between 2019 and 2023.
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