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A comprehensive analysis to reveal the underlying molecular mechanisms of natural killer cell in thyroid carcinoma based on single-cell RNA sequencing data.
Discov Oncol
January 2025
The Department of Experimental Medicine, Meishan City People's Hospital, No. 288, South Fourth Section, Dongpo Avenue, Meishan, 620000, Sichuan, China.
Background: Thyroid carcinoma (THCA) is the most common cancer of the endocrine system. Natural killer (NK) cell play an important role in tumor immune surveillance. The aim of this study was to explore the possible molecular mechanisms involved in NK cell in THCA to help the management and treatment of the disease.
View Article and Find Full Text PDFThe CD74 inhibitor DRhQ improves short-term memory and mitochondrial function in 5xFAD mouse model of Aβ accumulation.
Metab Brain Dis
January 2025
Department of Neurology, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Portland, OR, 97239, USA.
Neuroinflammation and mitochondrial dysfunction are early events in Alzheimer's disease (AD) and contribute to neurodegeneration and cognitive impairment. Evidence suggests that the inflammatory axis mediated by macrophage migration inhibitory factor (MIF) binding to its receptor, CD74, plays an important role in many central nervous system (CNS) disorders such as AD. Our group has developed DRhQ, a novel CD74 binding construct which competitively inhibits MIF binding, blocks macrophage activation and migration into the CNS, enhances anti-inflammatory microglia cell numbers and reduces pro-inflammatory gene expression.
View Article and Find Full Text PDFApproaches for Analyzing the Relationship Between Spirituality and Health Using Measures Contaminated with Indicators of Mental and Social Health.
J Relig Health
January 2025
School of Psychology & Public Health, College of Science, Health & Engineering, La Trobe University, Victoria, 3086, Australia.
There has been concern raised in religion/spirituality (R/S) research about the use of measures of spirituality that are contaminated by indicators of mental and/or social health. Many of these scales are used widely in published studies examining associations with health, and yet many researchers and reviewers are not aware of contamination issues. We have previously cautioned researchers to be careful in their choice of religious/spirituality (R/S) measures (Koenig and Carey in J Relig Health, 63(5):3729-3743.
View Article and Find Full Text PDFEmerging trends in nano-sensors: A new frontier in food safety and quality assurance.
Heliyon
January 2025
Department of Food Sensory and Cognitive Science, Research Institute of Food Science and Technology (RIFST), Mashhad, Iran.
The rapid evolution of nanotechnology has catalyzed significant advancements in the design and application of nano-sensors, particularly within the food industry, where ensuring safety and quality is of paramount concern. This review explores the multifaceted role of nano-sensors constructed from diverse nanomaterials in detecting foodborne pathogens and toxins, offering a comprehensive analysis of their operational principles, sensitivity, and specificity. Nano-sensors leverage unique physical and chemical properties at the nanoscale to enhance the detection of microbial contamination, actively contributing to food safety protocols.
View Article and Find Full Text PDFIdentification of novel ferroptosis-related biomarkers associated with the oxidative stress pathways in ischemic cardiomyopathy.
Int J Cardiol Heart Vasc
February 2025
Department of Geriatrics, Peking University Third Hospital, Beijing 100191, PR China.
Background: Ferroptosis is a cell death process that depends on iron and reactive oxygen species. It significantly contributes to cardiovascular diseases. However, its exact role in ischemic cardiomyopathy (ICM) is still unclear.
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