Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1139/m74-175 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Establishment of a human ovarian endometrioid carcinoma cell line by constitutive expression of cyclin-dependent kinase 4, cyclin D1 and telomerase reverse transcriptase.
Hum Cell
January 2025
Department of Tumor Pathology, Faculty of Medical Sciences, University of Fukui, 23-3 Matsuoka-Shimoaizuki, Eiheiji, Fukui, 910-1193, Japan.
Only a few human ovarian endometrioid carcinoma cell lines are currently available, partly due to the difficulty of establishing cell lines from low-grade cancers. Here, using a cell immortalization strategy consisting of i) inactivation of the p16-pRb pathway by constitutive expression of mutant cyclin-dependent kinase 4 (R24C) (CDK4) and cyclin D1, and ii) acquisition of telomerase reverse transcriptase (TERT) activity, we established a human ovarian endometrioid carcinoma cell line from a 46-year-old Japanese woman. That line, designated JFE-21, has proliferated continuously for over 6 months with a doubling time of ~ 55 h.
View Article and Find Full Text PDF[Frameshift mutation in gene causes amelogenesis imperfecta].
Beijing Da Xue Xue Bao Yi Xue Ban
February 2025
Department of Cariology and Endodontology, Peking University School and Hospital of Stomatology & National Center for Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices, Beijing 100081, China.
Objective: To analyze gene mutation found in a pedigree with clinical features and inheritable pattern consistent with amelogenesis imperfecta (AI) in China, and to study the relationship between its genotype and phenotype.
Methods: Clinical and radiological features were recorded for the affected individuals. Peripheral venous blood samples of the patient and family members were collected for further study, and the genomic DNA was extracted to identify the pathogenic gene.
Chloramphenicol and gentamicin reduce the evolution of resistance to phage ΦX174 by suppressing a subset of E. coli LPS mutants.
PLoS Biol
January 2025
Microbial Molecular Evolution Group, Department of Microbial Population Biology, Max Planck Institute for Evolutionary Biology, Plön, Germany.
Bacteriophages infect gram-negative bacteria by attaching to molecules present on the bacterial surface, often lipopolysaccharides (LPS). Modification of LPS can lead to resistance to phage infection. In addition, LPS modifications can impact antibiotic susceptibility, allowing for phage-antibiotic synergism.
View Article and Find Full Text PDFDetermination of streptococcus mutans retention in acidic and neutral pH artificial saliva environment of all-ceramic materials with different surface treatment.
BMC Oral Health
January 2025
Department of Basic Medical Science, Faculty of Medicine, Yozgat Bozok University, Yozgat, 66100, Türkiye, Turkey.
Background: Although surface finishing processes are effective against Streptococcus mutans biofilm, the mechanism of action of saliva with different acidity values has not been studied in detail. This study aims to produce four different all-ceramic materials in a single session with CAD/CAM devices and apply two different surface finishing processes, glazing and polishing, and then determine the retention of Streptococcus mutants on the surfaces of the materials in saliva with varying levels of acidity.
Methods: Zirconia-reinforced lithium silicate (Vita Suprinity, Vita Zahnfabrik, Bad Saöckingen, Germany), monochromatic feldspar (Vitablocs Mark 2, Vita Zahnfabrik, Bad Saöckingen, Germany), leucite glass ceramic (IPS Empress CAD, Ivoclar Vivadent, Liechtenstein), and monolithic zirconia (Incoris TZI (Cerec) Sirona, Germany) were used in the study.
A land plant-specific VPS13 mediates polarized vesicle trafficking in germinating pollen.
New Phytol
February 2025
Graduate School of Agricultural and Life Sciences, University of Tokyo, Tokyo, 113-8657, Japan.
Pollen has an extraordinary ability to convert from a dry state to an extremely rapidly growing state. During pollination, pollen receives water and Ca from the contacting pistil, which will be a directional cue for pollen tube germination. The subsequent rapid activation of directional vesicular transport must support the pollen tube growth, but the molecular mechanism leading to this process is largely unknown.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!