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CHARACTERIZATION OF THE ASSOCIATION BETWEEN BIRTHWEIGHT AND SEVERE POSTPARTUM HEMORRHAGE IN WOMEN WITH DELIVERY AT TERM.
Am J Obstet Gynecol
March 2025
Université Paris Cité, Institut Santé des femmes, U1153, Centre of Research In Epidemiology and Statistics (CRESS), Obstetrical, Perinatal and Paediatric Epidemiology Research Team (EPOpé), INSERM, INRAE, Paris, France; Department of Obstetrics and Gynecology, Hôpital Robert Debré, Assistance Publique-Hôpitaux de Paris, 48 Bd Sérurier, 75019 Paris, France.
Background: Macrosomia, classically defined by an arbitrary birthweight threshold, is associated with an increased risk of postpartum hemorrhage (PPH). However, some preliminary evidence suggests that lower birthweights may also be at increased risk. We hypothesized that birthweight, analyzed as a continuous variable, is significantly associated with the risk of severe postpartum hemorrhage, with the risk increasing not only at higher birthweights traditionally associated with macrosomia but also potentially at lower birthweights.
View Article and Find Full Text PDFTo rescue or not to rescue immature oocytes: Prospects and challenges.
Fertil Steril
March 2025
IVIRMA Global Research Alliance, Genera, Clinica Valle Giulia, Rome, Italy; Department of Biomolecular Sciences, University of Urbino 'Carlo Bo', Urbino, Italy. Electronic address:
In vitro maturation (IVM) of immature oocytes has been explored for research and clinical purposes since the dawn of assisted reproduction technologies. Oocyte maturation is a highly specific process, based on complex mutual relationships between the germ and somatic cell compartments. The complexity of this relationship has made the quest for achieving oocyte maturation in vitro arduous.
View Article and Find Full Text PDFBacterial estrogenesis without oxygen: Wood-Ljungdahl pathway likely contributed to the emergence of estrogens in the biosphere.
Proc Natl Acad Sci U S A
March 2025
Biodiversity Research Center, Academia Sinica, Taipei 115, Taiwan.
Androgen and estrogen, key sex hormones, were long thought to be exclusively produced by vertebrates. The O-dependent aromatase that converts androgen to estrogen (estrogenesis) has never been identified in any prokaryotes. Here, we report the finding of anaerobic estrogenesis in a Peptococcaceae bacterium ( sp.
View Article and Find Full Text PDFClinico-pathological characteristics of a distinct tumor phenotype: invasive lobular carcinoma with tubular elements (ILC-TE) in the WSG ADAPTcycle trial.
Lab Invest
March 2025
Institute of Pathology, Hannover Medical School, Carl-Neuberg-Str. 1, 30625 Hannover, Germany. Electronic address:
Background: Invasive lobular carcinoma with tubular elements (ILC-TE) is a recently identified variant of invasive lobular breast carcinoma (ILC). The histology of ILC-TE is defined by non-cohesive carcinoma cells mixed with cohesive tubular elements and complete loss of E-cadherin. Cell-cell adhesion is partially restored by switching from an E-cadherin-deficient to a P-cadherin-proficient status (EPS).
View Article and Find Full Text PDFConservative endometrioma surgery: The combined technique versus CO2-laser vaporization only (BLAST: Belgium LAser STudy): Clinical protocol for a multicenter randomized controlled trial.
PLoS One
March 2025
Department of Obstetrics and Gynecology, Leuven University Fertility Center, University Hospitals Leuven, Leuven, Belgium.
Background: The surgical management of endometrioma(s) remains challenging. Although laparoscopic surgery is a well-established treatment of endometrioma(s), caution is required to minimize ovarian damage. Several surgical techniques have been described to treat endometrioma(s): classical cystectomy, ablative techniques, or a combination of both.
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