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Reference-Based Standardization Approach Stabilizing Small Batch Risk Prediction via Polygenic Score.
Genet Epidemiol
March 2025
Division of Biomedical Information Analysis, Iwate Tohoku Medical Megabank Organization, Disaster Reconstruction Center, Iwate Medical University, Yahaba, Japan.
The polygenic score (PGS) holds promise for motivating preventive behavioral changes. However, no clinically validated standardization methodology currently exists. Here, we demonstrate the efficacy of a "reference-based" approach for standardization.
View Article and Find Full Text PDFDietary exposure to aflatoxin B1, aflatoxin G1, ochratoxin A, and patulin through fruit juice consumption: A probabilistic assessment of health risk.
Toxicol Rep
June 2025
Applied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
The present investigation assessed the risk of dietary exposure to four mycotoxins, namely aflatoxin B1 (AFB1), aflatoxin G1 (AFG1), ochratoxin A (OTA), and patulin (PAT) via fruit juice consumption for Iranian consumers. In 96 fruit juice samples obtained from Iran market, mycotoxins levels were determined using liquid chromatography-tandem mass spectrometry. Also, probabilistic health risk assessment was conducted in terms of tolerable daily intake percentage (%TDI) and under cancer risk scenarios.
View Article and Find Full Text PDFAssociation between heavy metals and risk of cardiovascular diseases in US adults with prediabetes from NHANES 2011-2018.
BMC Public Health
January 2025
Department of Epidemiology and Biostatistics, School of Public Health of Jilin University, Changchun, 130021, China.
Background: The association of plasma metals on the risk of cardiovascular diseases (CVD) in adults with prediabetes remains poorly investigated. To assess the association between plasma metal exposure and the risk of CVD in prediabetic adults in the United States using five plasma metals.
Methods: Five cycles of data (2011-2012, 2013-2014, 2015-2016, and 2017-2018) from the NHANES were adopted in this study.
Advancing ex vivo functional whole-organ prostate gland model for regeneration and drug screening.
Sci Rep
January 2025
Molecular Biology and Stem Cell Research Lab, Centre for Molecular and Nanomedical Sciences, International Research Centre, Sathyabama Institute of Science & Technology, Chennai, Tamilnadu, India.
Model organisms are vital for biomedical research and drug testing but face high costs, complexity, and ethical issues. While newer techniques like organoids and assembloids have shown improvements, they still remain inadequate in addressing all research needs. In this study, we present a new method for maintaining the prostate gland of the earthworm, Eudrilus eugeniae ex vivo and examine its potential for regeneration and drug screening.
View Article and Find Full Text PDFValidity of the Alberta Infants Motor Scale in Norwegian infants aged 6-9 months through comparison with Canadian and Dutch scores.
Front Pediatr
January 2025
Department of Health and Functioning, Faculty of Health and social science, Western Norway University of Applied Sciences, Bergen, Norway.
Introduction: The Alberta Infant Motor Scale (AIMS) is widely used to assess infant motor development but has shown limited cross-cultural validity in various populations. The distribution of the original AIMS scores has not been cross-culturally validated for Norwegian infants. This study aimed to evaluate the applicability of the Canadian AIMS norm reference for Norwegian infants aged 6-9 months and compare their percentile rankings with the Canadian and Dutch norms.
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