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Quantitative Insights into Processivity of an Hsp100 Protein Disaggregase on Folded Proteins.
Biophys J
January 2025
Department of Chemistry, University of Alabama at Birmingham, Birmingham, Alabama. Electronic address:
The Hsp100 family of protein disaggregases play important roles in maintaining protein homeostasis in cells. E. coli ClpB is an Hsp100 protein that solubilizes protein aggregates.
View Article and Find Full Text PDFExperimental Investigation on Macroscopic and Microscopic Mechanical Properties of Geopolymer-Stabilized Macadam.
Materials (Basel)
January 2025
School of Civil Engineering, Central South University, Changsha 410075, China.
Geopolymer, as a promising inorganic binding material, holds potential for use in constructing base layers for highway pavements. This study aims to evaluate the mechanical properties of geopolymer-stabilized macadam (GSM) at both the micro- and macro-scale by a series of tests, demonstrating that high-Ca GSM is a high-quality material for pavement base layers. The results demonstrated that GSM exhibits outstanding mechanical and fatigue properties, significantly surpassing those of cement-stabilized macadam (CSM).
View Article and Find Full Text PDFCo-Localized in Amyloid Plaques Cathepsin B as a Source of Peptide Analogs Potential Drug Candidates for Alzheimer's Disease.
Biomolecules
December 2024
Section of Cell Biology and Biophysics, Department of Biology, School of Sciences, National and Kapodistrian University of Athens, Panepistimiopolis, 157 01 Athens, Greece.
Alzheimer's disease (AD) is a complex neurodegenerative disorder characterized by extracellular amyloid plaques, predominantly consisting of amyloid- (A) peptides. The oligomeric form of A is acknowledged as the most neurotoxic, propelling the pathological progression of AD. Interestingly, besides A, other proteins are co-localized within amyloid plaques.
View Article and Find Full Text PDFStructural and topological analysis of thiosemicarbazone-based metal complexes: computational and experimental study of bacterial biofilm inhibition and antioxidant activity.
BMC Chem
January 2025
Chemistry Department, Faculty of Science, Alexandria University, Alexandria, Egypt.
The structural and electronic behavior of thiosemicarbazone (TSC)-based metal complexes of Mn (II), Fe (II), and Ni (II) have been investigated. The synthesized metal complexes were characterized using elemental analysis, magnetic susceptibility, molar conductivity, FTIR, and UV-Vis spectroscopy, the computational path helped with further structural investigation. The solubility test on the TSC and its complexes revealed their solubility in most organic solvents.
View Article and Find Full Text PDFNanosheet-shaped WS/ICG nanocomposite for photodynamic/photothermal synergistic bacterial clearance and cutaneous regeneration on infectious wounds.
Biomater Adv
January 2025
Key Laboratory of Tropical Translational Medicine of Ministry of Education, Hainan Medical University-The University of Hong Kong Joint Laboratory of Tropical Infectious Diseases, School of Basic Medical Sciences and Life Sciences, Hainan Medical University, Haikou 571199, China. Electronic address:
Bacterial infections present a significant threat to human health, a challenge that is intensified by the slow pace of novel antibiotic development and the swift emergence of bacterial resistance. The development of novel antibacterial agents is crucial. Indocyanine green (ICG), a widely used imaging dye, efficiently generates reactive oxygen species (ROS) and heat for treating bacterial infections but suffers from aggregation and instability, limiting its efficacy.
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