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Role of Dolutegravir/Lamivudine in the Management of Pregnant People Living with HIV-1: A Narrative Review.
Infect Dis Ther
December 2024
ViiV Healthcare, 980 Great West Road, Brentford, Middlesex, TW8 9GS, UK.
Article Synopsis
- Lowering viral load during pregnancy is crucial to reduce the risk of HIV-1 vertical transmission, and minimizing drug exposure to the fetus is a key principle.
- While Dolutegravir/lamivudine (DTG/3TC) shows high effectiveness and safety in non-pregnant individuals, its initial use in pregnant HIV-1 patients is not recommended due to limited data.
- Recent studies suggest that DTG/3TC may be effective and safe for pregnant individuals, showing high rates of viral suppression and no increased risk of neural tube defects, making it a potentially preferable option to more complex regimens.
Serum Anti-Aminoacyl-Transfer Ribonucleic Acid Synthetase Antibody Levels Are Involved in Rheumatoid Arthritis Complicated with Interstitial Lung Disease.
J Clin Med
November 2024
Department of Rheumatology, NHO Tokyo National Hospital, Kiyose 204-8585, Japan.
A common complication in patients with rheumatoid arthritis (RA) is interstitial lung disease (ILD). Antibodies (Abs) to anti-aminoacyl-transfer ribonucleic acid synthetase (ARS) are linked to ILD in patients with idiopathic inflammatory myopathies (IIM). There have been limited studies of anti-ARS Abs in RA.
View Article and Find Full Text PDFLinks between Nosocomial Endodontic Infections and Bacteremia Associated with Apical Periodontitis and Endodontic Treatment.
J Endod
November 2024
Department of Endodontics, Faculty of Dentistry, Oral & Craniofacial Sciences, Centre of Oral Clinical & Translational Sciences, Guy's Dental Hospital, King's College London, London, UK. Electronic address:
Introduction: Nosocomial endodontic infections can cause treatment failure and are potential risk of bacteremia. This study is aimed to investigate bacteremia associated with apical periodontitis and immediate postendodontic treatment using next-generation sequencing. The study will also elucidate if the endodontic nosocomial pathogens are present in the blood microbiome.
View Article and Find Full Text PDFA Glimpse of Noncoding RNAs: Secondary Structure, Emerging Trends, and Potential Applications in Human Diseases.
Methods Mol Biol
November 2024
The Steve and Cindy Rasmussen Institute for Genomic Medicine, Nationwide Children's Hospital, Columbus, OH, USA.
An appealing strategy for the treatment of several diseases is the therapeutic targeting of noncoding RNAs (ncRNAs), such as microRNAs (miRNAs) and long noncoding RNAs (lncRNAs). Many antisense oligonucleotides and small interfering RNAs have been tested in clinical studies over the past 10 years, and several of these have received FDA approval. However, trial results have thus far been mixed, with some studies reporting strong effects and others showing low effectiveness or side effects, including toxicity.
View Article and Find Full Text PDFPeptide Nucleic Acids in Saturation Transfer Difference Nuclear Magnetic Resonance Experiments: A Simple and Valuable Tool for Studying HuR-Small Molecule Complexes.
ACS Omega
November 2024
Department of Drug Sciences, University of Pavia, Via Taramelli 12, Pavia 27100, Italy.
Ribonucleic acid (RNA)-binding proteins (RBPs) play a key role in regulating RNA stability, fate, function, gene expression, post-transcriptional modifications, and cellular activities. Among the various RBPs identified to date, the Hu proteins have been the most extensively studied. Specifically, HuR influences several cellular processes, including cell proliferation, differentiation, and stress response, and it is frequently overexpressed in various solid tumors.
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