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Trans-Nerolidol Protects Against Myocardial Ischemia via Downregulating Cytochrome- and Caspases-Signaling Pathways in Isoproterenol-Induced Rats.
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Hainan Provincial Key Laboratory of Resources Conservation and Development of Southern Medicine, Hainan Branch of the Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Peking Union Medical College, Haikou 570311, China.
is widely used to treat cardiovascular diseases. Our research group found that volatile oil has a good anti-myocardial ischemic effect, and its main pharmacodynamic components are trans-nerolol and its oxides. However, the exact mechanisms underlying this effect have not yet been elucidated.
View Article and Find Full Text PDFRetrograde Transport of Tobacco Phytaspase Is Mediated by Its Partner, Tubby-like F-Box Protein 8.
Int J Mol Sci
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Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Moscow 119991, Russia.
Phytaspases, plant cell death-promoting and proprotein-processing proteolytic enzymes of the plant subtilase family, display aspartate (caspase-like) cleavage specificity and a very unusual retrograde trafficking from the apoplast to the cell interior upon induction of death-inducing stresses. To determine the underlying molecular mechanisms, we performed a search for tobacco phytaspase (Phyt) interactors using an in vivo cross-linking approach in plants. Tobacco Tubby-like F-box protein 8 (named Tubic hereafter) was identified as an Phyt interactor, with formation of the cross-linked complex being only efficient under the oxidative stress conditions.
View Article and Find Full Text PDFSynthesis, Physicochemical Properties and Anti-Fungal Activities of New -Arylporphyrins.
Int J Mol Sci
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Université de Lorraine, CNRS, LCPM, F-54000 Nancy, France.
In this work, we describe the synthesis of three new -arylporphyrins, named -tetrakis [4-(nicotinoyloxy)phenyl] porphyrin (), -tetrakis [4-(picolinoyloxy)phenyl] porphyrin (), and -tetrakis [4-(isonicotinoyloxy) phenyl] porphyrin (). These new synthesized -arylporphyrins are characterized using spectroscopic analysis: Fourier Transform Infrared Spectroscopy (FTIR) and One-dimensional Nuclear Magnetic Resonance (1D NMR), and mass spectrometry (MS). The photophysical studies (UV-visible absorption, singlet oxygen (O) luminescence, and fluorescence emissions) demonstrate their potential uses as photosensitizers (PSs) in photodynamic therapy (PDT) applications.
View Article and Find Full Text PDFInter-organ correlations in inflammation regulation: a novel biological paradigm in a murine model.
J Med Life
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Faculty of Medicine, Hebrew University, Jerusalem, Isreal.
Interactions between immune system constituents are mediated through direct contact or the transfer of mediators. The study aimed to assess the correlation between system components and out-of-body signals in a model of liver inflammation. In the first experiment, mice injected with Concanavalin A (ConA) were housed in a cage with a tube on top containing healthy livers or livers harvested from mice injected with ConA.
View Article and Find Full Text PDFRole of aspartate 42 and histidine 79 in the aiPLA activity and oligomeric status of Prdx6 at low pH.
Sci Rep
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Department of Biotechnology, Manipur University, Imphal, Manipur, 795003, India.
Peroxiredoxin 6 (Prdx6), a unique non-seleno peroxidase, is a bifunctional protein with GSH peroxidase at pH 7.4 and calcium independent phospholipase A (aiPLA) activities at pH 4.0.
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