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Maternal age is highly associated with non-chromosomal congenital anomalies: Analysis of a population-based case-control database.
BJOG
September 2023
Department of Obstetrics and Gynaecology, Semmelweis University, Budapest, Hungary.
Objective: The role of maternal age in the development of non-chromosomal congenital anomalies (NCAs) is under debate. Therefore, the primary aim of this study was to identify the age groups at risk for NCAs. The secondary aim was to perform a detailed analysis of the relative frequency of various anomalies.
View Article and Find Full Text PDFEpidemiology of Pierre-Robin sequence in Europe: A population-based EUROCAT study.
Paediatr Perinat Epidemiol
September 2021
Paediatric Department, Hospital Lillebaelt, Kolding, Denmark.
Article Synopsis
- Pierre Robin sequence (PRS) is a rare birth defect primarily causing respiratory and feeding challenges, and this study aimed to understand its epidemiology through data collected across Europe from 1998-2017.
- Out of over 11 million births, 1,294 cases of PRS were identified, resulting in a prevalence rate of 12 per 100,000 births, with isolated cases being more common than those associated with other anomalies.
- Findings indicated that older maternal age is linked to a higher prevalence of PRS, while survival rates were significantly lower for cases with additional chromosomal or structural anomalies compared to isolated cases, suggesting a need for further research into the factors contributing to PRS.
Advanced maternal age and risk of non-chromosomal anomalies: data from a tertiary referral hospital in Turkey.
J Matern Fetal Neonatal Med
March 2019
c Kanuni Sultan Suleyman Training and Research Hospital, Perinatology Clinic, Istanbul , Turkey.
Purpose: The purpose of this study is to determine if there is a relationship between non-chromosomal fetal anomalies of various organ systems and advanced maternal age.
Materials And Method: This study was conducted in 387 women aged 20-53 years who underwent fetal karyotype testing due to positive prenatal test results or advanced maternal age at the Kanuni Sultan Süleyman Training and Research Hospital between September 2011 and March 2015. Fetuses with chromosomal anomalies were excluded from the study.
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