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A possible role for VPS13-family proteins in bulk lipid transfer, membrane expansion and organelle biogenesis.
J Cell Sci
March 2022
Department of Cell Biology, Yale School of Medicine, New Haven, CT 06520, USA.
At organelle-organelle contact sites, proteins have long been known to facilitate the rapid movement of lipids. Classically, this lipid transport involves the extraction of single lipids into a hydrophobic pocket on a lipid transport protein. Recently, a new class of lipid transporter has been described with physical characteristics that suggest these proteins are likely to function differently.
View Article and Find Full Text PDFDefining cancer cachexia in head and neck squamous cell carcinoma.
Clin Cancer Res
November 2007
Doris Duke Clinical Research Fellowship, Verne S. Caviness General Clinical Research Center, and Department of Otolaryngology-Head and Neck Surgery, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA.
Purpose: Cancer cachexia is a devastating and understudied illness in patients with head and neck squamous cell carcinoma (HNSCC). The primary objective was to identify clinical characteristics and serum levels of cytokines and cachexia-related factors in patients with HNSCC. The secondary objective was to detect the occurrence of cytokine and cachexia-related factor gene expression in HNSCC tumors.
View Article and Find Full Text PDFTranscript profiles and deduced changes of metabolic pathways in maternal and filial tissues of developing barley grains.
Plant J
February 2004
Institut für Pflanzengenetik und Kulturpflanzenforschung (IPK), Correnstrasse 3, D-06466 Gatersleben, Germany.
Different aspects of barley grain development have been studied in detail, but a more global analysis of gene expression patterns is still missing. We have employed macro arrays, containing 1184 unique sequences from 1421 barley cDNA fragments, to study gene expression profiles in maternal and filial tissues of developing barley caryopses from fertilization to early storage phase. Principle component analysis (PCA) defined distinct expression networks in the pre-storage (0, 2, and 4 days after flowering (DAF)) and early storage phase (10 and 12 DAF).
View Article and Find Full Text PDFMolecular analysis of lipid-depleting factor in a colon-26-inoculated cancer cachexia model.
Int J Cancer
September 2002
Environmental Science Center, University of Tokyo, Japan.
Cachexia in cancer is characterized by progressive emaciation involving depletion of host adipose tissue stores, the molecular mechanism of which remains largely unknown. In this study, we have attempted to clarify the biologic characteristics of lipid-depleting factor in a mouse cachexia model. Utilizing differentiated 3T3-L1 adipocytes, we established an assay method quantifying the lipid-depleting activity in plasma derived from colon-26-inoculated mice and then analyzed the associated molecular mechanism.
View Article and Find Full Text PDFVisceral obesity: a "civilization syndrome".
Obes Res
May 1993
Department of Heart and Lung Diseases, Sahlgren's Hospital, University of Göteborg, Göteborg, Sweden.
The controversial question of the relationship between obesity and disease has been considerably clearer after the demonstration in several prospective, epidemiological studies that the subgroup of central, visceral obesity is particularly prone to develop cardiovascular disease, stroke, and non-insulin dependent diabetes mellitus. Visceral obesity is associated with multiple central endocrine aberrations. The hypothalamo-adrenal axis is apparently sensitive to stimuli, sex steroid hormone secretion blunted, and hyperandrogenicity is found in women.
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